The Long-term Effect of Different Exercise Intensities on High-Density Lipoprotein Cholesterol in Older Men and Women Using the Per Protocol Approach: The Generation 100 Study
| Autor: | Dorthe Stensvold, Kjetil Retterstøl, Ulrik Wisløff, Ida Berglund, Elisabeth Kleivhaug Vesterbekkmo, Stian Lydersen, Maria A. Fiatarone Singh, Jørn Wulff Helge, Sigmund A. Anderssen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (General) HRpeak peak heart rate CVD cardiovascular disease Interval training HDL-C high-density lipoprotein cholesterol chemistry.chemical_compound High-density lipoprotein R5-920 Internal medicine Heart rate medicine Vo2peak peak oxygen uptake business.industry Cholesterol HIIT high-intensity interval training VO2 max LMA lipid-modifying agent Continuous training chemistry CON control Exercise intensity Original Article LDL-C low-density lipoprotein cholesterol MICT moderate-intensity continuous training business High-intensity interval training |
| Zdroj: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 5, Pp 859-871 (2021) Mayo Clinic Proceedings: Innovations, Quality & Outcomes (MCP:IQ&O) Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| ISSN: | 2542-4548 |
| Popis: | Objective To examine whether 5 years of high-intensity interval training (HIIT) increases high-density lipoprotein cholesterol (HDL-C) concentration more than moderate-intensity continuous training (MICT) and control (CON) in older men and women. Methods A total of 1567 older adults (790 [50.4%] women) were randomized (2:1:1) to either CON (n=780; asked to follow the national recommendations for physical activity) or 2 weekly sessions of HIIT (10-minute warm-up followed by 4×4-minute intervals at ∼90% of peak heart rate) or MICT (50 minutes of continuous work at ∼70% of peak heart rate). Serum HDL-C concentration was measured by standard procedures at baseline and at 1 year, 3 years, and 5 years. The study took place between August 21, 2012, and June 31, 2018. Linear mixed models were used to determine between-group differences during 5 years using the per protocol approach. Results Men in HIIT had a smaller reduction in HDL-C (−1.2%) than men in CON (−6.9%) and MICT (−7.8%) after 5 years (P=.01 and P=.03 for CON vs HIIT and MICT vs HIIT, respectively). No effect of exercise intensity on HDL-C was seen in women. Changes in peak oxygen uptake were associated with changes in HDL-C in both men and women, whereas changes in body weight and fat mass were not. Conclusion In men, HIIT seems to be the best strategy to prevent a decline in HDL-C during a 5-year period. No effect of exercise intensity was seen for older women. Trial registration ClinicalTrials.gov identifier: NCT01666340. |
| Databáze: | OpenAIRE |
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