Prognostic Value of Obesity on Both Overall Mortality and Cardiovascular Disease in the General Population
Autor: | Juan Antonio Divisón-Garrote, Isabel Ponce-García, Geva, Luis Miguel Artigao-Ródenas, Damian Robert James Martínez-St. John, Francisco Botella-Romero, Marta Simarro-Rueda, Vicente Francisco Gil-Guillén, Julio Antonio Carbayo-Herencia, Antonio Palazón-Bru |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Cardiovascular event
Male medicine.medical_specialty Population lcsh:Medicine Disease Classification of obesity Diabetes mellitus medicine Humans Obesity education lcsh:Science Survival analysis education.field_of_study Multidisciplinary business.industry lcsh:R Middle Aged medicine.disease Prognosis Survival Analysis Surgery Treatment Outcome Cardiovascular Diseases Spain lcsh:Q Female business Body mass index Demography Research Article Follow-Up Studies |
Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 5, p e0127369 (2015) |
ISSN: | 1932-6203 |
Popis: | Background Obesity represents an important health problem and its association with cardiovascular risk factors is well-known. The aim of this work was to assess the correlation between obesity and mortality (both, all-cause mortality and the combined variable of all-cause mortality plus the appearance of a non-fatal first cardiovascular event) in a general population sample from the south-east of Spain. Materials and Methods This prospective cohort study used stratified and randomized two-stage sampling. Obesity [body mass index (BMI) ≥30 kg/m2] as a predictive variable of mortality and cardiovascular events was assessed after controlling for age, sex, cardiovascular disease history, high blood pressure, diabetes mellitus, hypercholesterolemia, high-density lipoprotein/triglycerides ratio, total cholesterol and smoking with the Cox regression model. Results The mean follow-up time of the 1,248 participants was 10.6 years. The incidence of all-cause mortality during this period was 97 deaths for every 10,000 person/years (95% CI: 80–113) and the incidence of all-cause mortality+cardiovascular morbidity was 143 cases for every 10,000 person/years (95% CI: 124–163). A BMI ≥35 kg/m2 yielded a hazard ratio for all-cause mortality of 1.94 (95% CI: 1.11–3.42) in comparison to non-obese subjects (BMI |
Databáze: | OpenAIRE |
Externí odkaz: |