Brain distribution of vasoactive intestinal peptide receptors following REM sleep deprivation
| Autor: | Fabio García-García, José-Luis Mendoza-Ramírez, René Drucker-Colín, Anabel Jiménez-Anguiano, Adalberto Durán-Vázquez |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Vasoactive intestinal peptide Rapid eye movement sleep Sleep REM REM rebound Prosencephalon Internal medicine mental disorders medicine Animals Diencephalon Rats Wistar Habituation Psychophysiologic Receptor Molecular Biology Brain Chemistry musculoskeletal neural and ocular physiology General Neuroscience medicine.disease Sleep in non-human animals Privation Rats Sleep deprivation Endocrinology Forebrain Autoradiography Receptors Vasoactive Intestinal Peptide Sleep Deprivation Neurology (clinical) medicine.symptom Psychology hormones hormone substitutes and hormone antagonists psychological phenomena and processes Brain Stem Developmental Biology |
| Zdroj: | Brain Research. 728:37-46 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(96)00374-5 |
| Popis: | Vasoactive intestinal peptide (VIP) has been shown to increase rapid eye movement (REM) sleep in normal and insomniac animals, while the administration of anti-VIP antibodies or an antagonist of VIP receptors decreases REM sleep. In addition, recently, it has been suggested that a VIP-like substance accumulates in the CSF during waking and that it may be involved in the production of the REM rebound normally seen following REM sleep deprivation. This evidence suggests that VIP may be important in modulating REM sleep in normal conditions and during REM sleep rebound. To determine whether VIP is involved in REM sleep homeostasis, VIP receptors of discrete brain areas was determined by autoradiography after 24 and 72 h of REM sleep deprivation (REM SD) by the water tank technique. Since this procedure has been suggested to produce some stress, an additional group adapted for 7 days to the sleep deprivation situation was tested. The results showed that REM SD produces an increase in the density of VIP receptors in several brainstem and forebrain structures at 24 h of REM SD and more so at 72 h of REM SD. Interestingly, results showed that habituation to the REM SD procedure decreases the density of VIP receptors in some areas of the brain of the REM sleep-deprived rats. The results are discussed in terms of the possibility that waking induces an increase of VIP receptors in several structures, which in turn are responsible for modulating REM sleep, but that stress contributes in part to VIP receptor changes. |
| Databáze: | OpenAIRE |
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