The graduated embryo score predicts the outcome of assisted reproductive technologies better than a single day 3 evaluation and achieves results associated with blastocyst transfer from day 3 embryo transfer
| Autor: | Geoffrey Sher, Levent Keskintepe, Jeffrey D Fisch, Mark Adamowicz |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty animal structures Fertilization in Vitro Reproductive technology Biology Andrology Pregnancy medicine Humans Blastocyst Gynecology Blastocyst Transfer Pregnancy Outcome Obstetrics and Gynecology Embryo Transfer medicine.disease Embryo transfer Pregnancy rate Treatment Outcome medicine.anatomical_structure Reproductive Medicine Private practice embryonic structures Gestation Female |
| Zdroj: | Fertility and Sterility. 80:1352-1358 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2003.05.013 |
| Popis: | Objective To evaluate the graduated embryo score (GES) for predicting assisted reproductive technology (ART) outcome compared to a single morphologic evaluation on day 3 of culture (grade A: ≥7 cells; Design Prospective cohort analysis. Setting Private practice. Patient(s) Women aged Intervention(s) Embryos were graded by GES and by day 3 morphologic characteristics alone before ET. Cycle outcomes were compared with embryo grade. Main outcome measure(s) Ongoing gestation and implantation rates. Result(s) Overall ongoing gestation and implantation rates were 48% and 26%, respectively. With 1+ embryo GES ≥70 (n = 77), the rates were 62% and 36%, respectively, which were significantly higher than for those with 0 embryos GES ≥70 (n = 29). With 1+ grade A embryo (n = 102), the rates were 50% and 27%, respectively. Transfer of more than one embryo GES ≥70 did not improve the pregnancy rate, but did increase the risk of multiple gestations. A single day 3 evaluation had an extremely low specificity (7%) compared to GES (47%). Graduated embryo scoring (GES) was an excellent predictor of pregnancy and implantation rates from blastocyst transfer. Day of transfer did not affect pregnancy rates, although implantation was higher from day 5 embryo transfer (ET) than from day 3 ET, as fewer embryos were transferred. Conclusion(s) Transfer of one or more embryo GES ≥70 predicts pregnancy and implantation rates better than a single morphologic evaluation on day 3 and achieves ART outcomes associated with blastocyst transfer from day 3 ET, making extended culture unnecessary for most patients. |
| Databáze: | OpenAIRE |
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