Nuclear Receptors and Development of Marine Invertebrates
| Autor: | Laura Canesi, Isa D. L. Gomes, Michael Schubert, A. Miglioli, Rémi Dumollard |
|---|---|
| Přispěvatelé: | Laboratoire de Biologie du Développement de Villefranche sur mer (LBDV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Aquatic Organisms marine invertebrates lcsh:QH426-470 [SDV]Life Sciences [q-bio] Regulator Receptors Cytoplasmic and Nuclear nuclear receptors Context (language use) Review Biology DNA sequencing Evolution Molecular 03 medical and health sciences Transactivation 0302 clinical medicine Genetics Animals Transcription factor development Genetics (clinical) Phylogeny ComputingMilieux_MISCELLANEOUS evolutionary developmental biology nuclear receptors evolutionary developmental biology Marine invertebrates Invertebrates lcsh:Genetics 030104 developmental biology [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis Nuclear receptor Evolutionary biology Evolutionary developmental biology 030217 neurology & neurosurgery |
| Zdroj: | Genes Genes, MDPI, 2021, 12 (1), pp.83. ⟨10.3390/genes12010083⟩ Genes, Vol 12, Iss 83, p 83 (2021) |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes12010083⟩ |
| Popis: | International audience; Nuclear Receptors (NRs) are a superfamily of transcription factors specific to metazoans that have the unique ability to directly translate the message of a signaling molecule into a transcriptional response. In vertebrates, NRs are pivotal players in countless processes of both embryonic and adult physiology, with embryonic development being one of the most dynamic periods of NR activity. Accumulating evidence suggests that NR signaling is also a major regulator of development in marine invertebrates, although ligands and transactivation dynamics are not necessarily conserved with respect to vertebrates. The explosion of genome sequencing projects and the interpretation of the resulting data in a phylogenetic context allowed significant progress toward an understanding of NR superfamily evolution, both in terms of molecular activities and developmental functions. In this context, marine invertebrates have been crucial for characterizing the ancestral states of NR-ligand interactions, further strengthening the importance of these organisms in the field of evolutionary developmental biology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|