Effect of the Combination of Ketorolac and Bupivacaine on Transversus Abdominis Plane Block for Postoperative Analgesia After Gynecological Laparoscopic Surgery
| Autor: | Jing Jiao, Xiao-Min Zhou, Shaoqiang Huang, Qi Jiang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Laparoscopic surgery Adolescent Sufentanil Nausea medicine.medical_treatment 030204 cardiovascular system & hematology law.invention Young Adult 03 medical and health sciences Gynecologic Surgical Procedures 0302 clinical medicine Randomized controlled trial law Transversus Abdominis Plane Block medicine Humans Pain Management Single-Blind Method Anesthetics Local Abdominal Muscles Pain Measurement Bupivacaine Pain Postoperative Morphine business.industry Analgesia Patient-Controlled Nerve Block General Medicine Middle Aged Analgesics Opioid Ketorolac Patient Satisfaction 030220 oncology & carcinogenesis Anesthesia Vomiting Drug Therapy Combination Female Laparoscopy medicine.symptom business Anesthetics Intravenous medicine.drug |
| Zdroj: | Medical Science Monitor. 26 |
| ISSN: | 1643-3750 |
| Popis: | BACKGROUND This study assessed the additional benefits of bupivacaine when combined with ketorolac for transversus abdominis plane (TAP) block after gynecological laparoscopic surgery. MATERIAL AND METHODS This randomized, observer-blind trial recruited 153 patients who underwent gynecological laparoscopic surgery. Patients were randomly assigned to receive bupivacaine combined with ketorolac 15 mg/side for TAP block (TK group), bupivacaine for TAP block and 30 mg postoperative intravenous ketorolac (T group), or 30 mg postoperative intravenous ketorolac alone (C group). The primary endpoints included consumption of sufentanil for 24 h postoperatively, actual press times of the patient-controlled analgesia (PCA) pump, and effective press times of the PCA pump, whereas the secondary endpoints included numerical rating scale (NRS) pain scores at rest and during activity, satisfaction with analgesia, episodes of nausea and vomiting and length of hospital stay. RESULTS Sufentanil consumption, actual press times of the PCA pump, and effective press times of the PCA pump were lower in the TK and T groups than in the C group. NRS scores at rest and during activity at 1, 2, 4, 6, and 24 hours were significantly lower in the TK and T groups than in the C group. The TK and T groups showed greater satisfaction with analgesia than the C group, while the TK group showed greater overall satisfaction than the C group. Lengths of stay, rates of nausea and vomiting, and venting times did not differ significantly among the three groups. CONCLUSIONS Combined ketorolac and bupivacaine as TAP block improved the effectiveness of analgesia without increasing adverse events. Trial registration number: ChiCTR1900022577. |
| Databáze: | OpenAIRE |
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