Rate of disappearance of exogenous dog renin from the plasma of nephrectomized dogs
| Autor: | Tatiana A. Assaykeen, William F. Ganong, K. Otsuka |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Chemistry medicine.medical_treatment Angiotensin II Endogeny Blood Pressure Kidney Plasma renin activity Nephrectomy General Biochemistry Genetics and Molecular Biology Rats Endocrinology Dogs Internal medicine Renin–angiotensin system Renin medicine Animals |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 127(1) |
| ISSN: | 0037-9727 |
| Popis: | SummaryExogenous dog renin was administered intravenously to nephrectomized dogs and its disappearance followed for 3 hours. There were two exponential components to the disappearance curves, a rapid component with an average half-time of 6 ± 1 min and a slower component with an average half-time of 79 ± 7 min. Circulating angiotensin levels were shown to have no effect on either half-time value and the presence of adequate substrate was demonstrated. The mean plasma renin level in pentobarbital-anesthetized dogs was found to be 10.2 ± 1.0 mμg angiotensin II generated/ml/3 hours. Four hours after nephrectomy, it was 1.3 ± 0.2 mμg. This suggests that the half-time of endogenous renin is similar to that of exogenous renin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|