| Autor: |
Tingting Liang, Ping Zhao, Xiao Zhang, Xuedan Han, Bo Hong, Lingsheng Kong, Huanxian Chang, Liyan Liu |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Experimental and therapeutic medicine. 23(6) |
| ISSN: |
1792-1015 |
| Popis: |
Forkhead box A1 (FOXA1) plays an important role in the central nervous system, and its loss can lead to the downregulation of tyrosine hydroxylase, which directly affects the synthesis of dopamine, thus leading to Parkinson's disease (PD). The present study aimed to explore the specific role of FOXA1 in PD. Blood samples from patients with PD were collected to determine the expression levels of FOXA1 using reverse transcription-quantitative PCR (RT-qPCR). In addition, mouse dopaminergic neuron MES23.5 cells were induced with 6-hydroxydopamine (6-OHDA) to construct an |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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