Development of poorly differentiated adenocarcinoma and carcinoid due to long-term Helicobacter pylori colonization in Mongolian gerbils
| Autor: | Shiro Takagi, Yoshito Yokoyama, Keiichiro Haga, Eiji Iwao, Shuichi Hanada, Fumihiro Hirayama |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Duodenum animal diseases Carcinoid Tumor Biology Adenocarcinoma Gerbil Gastroenterology Helicobacter Infections Time Stomach Neoplasms Internal medicine parasitic diseases Gastrins medicine Animals Colonization Intestinal Mucosa Metaplasia Stomach Cancer Helicobacter pylori Hepatology medicine.disease Pylorus biology.organism_classification Antibodies Bacterial digestive system diseases Disease Models Animal medicine.anatomical_structure nervous system Immunoglobulin G sense organs Gerbillinae |
| Zdroj: | Journal of gastroenterology. 34(4) |
| ISSN: | 0944-1174 |
| Popis: | A Mongolian gerbil model was used to clarify whether long-term colonization by Helicobacter pylori is an important risk factor for the development of gastric cancer. Fifty-nine gerbils (3 controls and 56 gerbils inoculated with H. pylori) were killed at various times (average, 23 months) more than 12 months after H. pylori inoculation. In the H. pylori-inoculated group, poorly differentiated adenocarcinoma was observed in the pylorus of 1 gerbil, and carcinoid was observed in the fundus of the stomach in 18 gerbils. No lesions were found in the stomachs of the 3 control gerbils. The results imply that long-term colonization by H. pylori is an important risk factor for the development of gastric adenocarcinoma and carcinoid. |
| Databáze: | OpenAIRE |
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