Thulium-170-Labeled Microparticles for Local Radiotherapy: Preliminary Studies
| Autor: | Julianna Thuróczy, András Polyák, Csaba Jakab, Veronika Haász, Sudipta Chakraborty, Gergely Jánoki, Robert Peter Joba, M. R. A. Pillai, Gyozo A. Janoki, Gabriella Dabasi, Zita Pöstényi, Tapas Das, Réka Király, Lajos Balogh |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Cancer Research Materials science chemistry.chemical_element law.invention Dogs Optical microscope Dynamic light scattering law Animals Tissue Distribution Radiology Nuclear Medicine and imaging Irradiation Particle Size Radioisotopes Tomography Emission-Computed Single-Photon Pharmacology Synovitis business.industry Synovial Membrane Radiochemistry General Medicine Tin oxide Thulium Oncology chemistry Transmission electron microscopy Radionuclide therapy Particle Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | Cancer Biotherapy and Radiopharmaceuticals. 29:330-338 |
| ISSN: | 1557-8852 1084-9785 |
| DOI: | 10.1089/cbr.2014.1680 |
| Popis: | The present article describes the preparation, characterization, and biological evaluation of Thulium-170 ((170)Tm) [T1/2 = 128.4 days; Eβmax = 968 keV; Eγ = 84 keV (3.26%)] labeled tin oxide microparticles for its possible use in radiation synovectomy (RSV) of medium-sized joints. (170)Tm was produced by irradiation of natural thulium oxide target. 170Tm-labeled microparticles were synthesized with high yield and radionuclidic purity (99%) along with excellent in vitro stability by following a simple process. Particle sizes and morphology of the radiolabeled particles were examined by light microscope, dynamic light scattering, and transmission electron microscope and found to be of stable spherical morphology within the range of 1.4-3.2 μm. The preparation was injected into the knee joints of healthy Beagle dogs intraarticularly for biological studies. Serial whole-body and regional images were taken by single-photon-emission computed tomography (SPECT) and SPECT-CT cameras up to 9 months postadministration, which showed very low leakage (8% of I.D.) of the instilled particles. The majority of leaked radiocolloid particles were found in inguinal lymph nodes during the 9 months of follow-up. All the animals tolerated the treatment well; the compound did not show any possible radiotoxicological effect. These preliminary studies showed that 170Tm-labeled microparticles could be a promising nontoxic and effective radiopharmaceutical for RSV applications or later local antitumor therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|