Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation
| Autor: | K L Stell, Richard J. Gulizia, Donald E. Mosier, Gary L. Gilmore, Bruce E. Torbett |
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| Rok vydání: | 1993 |
| Předmět: |
Adoptive cell transfer
T-Lymphocytes T cell Immunology Congenic Mice SCID Mice medicine Animals Immunology and Allergy B cell B-Lymphocytes Mice Inbred BALB C Genes Immunoglobulin biology Homozygote Articles T lymphocyte Virology Allotype medicine.anatomical_structure Animals Newborn Immunoglobulin M Mutation biology.protein Antibody |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.177.1.191 |
| Popis: | The autosomal recessive scid mutation results in defective immunoglobulin and T cell receptor gene rearrangement. The scid mutation occurred in the allotype congenic C.B-17 line, and up to 25% of C.B-17 scid mice spontaneously produce both T cells and immunoglobulin, a phenotype known as "leaky." Moreover, introduction of neonatal T cells into C.B-17 scid mice leads to immunoglobulin production by 100% of animals. We have produced mice homozygous for both the scid and beige mutations. By contrast with C.B-17 scid mice, BALB/c scid.beige mice have a < 2% incidence of "leakiness." This percentage does not increase with age, and introduction of neonatal T cells fails to rescue immunoglobulin production. This suggests that a gene (or genes) closely linked to the beige locus regulates B and/or T cell development. |
| Databáze: | OpenAIRE |
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