Glycosyltransferase B4GALNT1 and type 1 diabetes in Croatian population
| Autor: | Tatijana Zemunik, Gordana Stipančić, Vesela Torlak, Jasminka Jakšić, Zrinka Kačić, Anita Špehar Uroić, Veselin Škrabić, Vesna Boraska, Anita Markotić |
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| Rok vydání: | 2009 |
| Předmět: |
education.field_of_study
Ganglioside Clinical Biochemistry Population Glycosyltransferase Gene Autoantibody General Medicine Biology Biochemistry type 1 diabetes glycosyltransferase B4GALNT1 GalNAc-T ganglioside tag polymorphism association analysis Croatia B4GALNT1 Gene Glycosyltransferase biology.protein education Gene Genetic association |
| Zdroj: | Clinical Biochemistry. 42:819-822 |
| ISSN: | 0009-9120 |
| Popis: | Objectives Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by destruction of pancreatic β cells. Gangliosides are thought to be a target of a variety of anti-islet autoantibodies. The formation of gangliosides is catalyzed by addition of sugar residues to complex glycoconjugate molecules by glycosyltransferases. Beta-1,4-N-acetyl-galactosaminyl transferase 1 is the enzyme involved in the synthesis of asialo, a, b and c-series gangliosides and it is coded by B4GALNT1 gene. Design and methods We genotyped 2 B4GALNT1 tagSNPs, designed to capture 100% of common variation in the region, in 202 families and 199 controls from the Croatian population. Results Transmission disequilibrium test and case-control analysis did not detect an association of B4GALNT1 gene with T1DM. Conclusions Expression of gangliosides requires coordinated work of many genes. There is enough evidence showing that gangliosides are plausible contributors to T1DM pathological processes and, therefore, future studies on different glycosyltransferase genes are necessary. |
| Databáze: | OpenAIRE |
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