Association of parathyroid hormone and vitamin D with untreated hypertension: Is it different in white-coat or sustained hypertension?

Autor: Hakan Çetin, Turgay Erten, Alper Serçelik, Ferit Akgül
Přispěvatelé: Zonguldak Bülent Ecevit Üniversitesi
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Physiology
Peptide Hormones
lcsh:Medicine
Parathyroid hormone
Organic chemistry
White coat hypertension
Blood Pressure
030204 cardiovascular system & hematology
Biochemistry
Vascular Medicine
Body Mass Index
Geographical Locations
0302 clinical medicine
Medicine and Health Sciences
Vitamin D
lcsh:Science
Multidisciplinary
Drugs
Vitamins
Middle Aged
Turkey (Country)
Physical sciences
Europe
Chemistry
Physiological Parameters
Parathyroid Hormone
Hypertension
Female
White Coat Hypertension
Research Article
medicine.medical_specialty
Asia
Diastole
030209 endocrinology & metabolism
03 medical and health sciences
Chemical compounds
Thyroid-stimulating hormone
Internal medicine
Organic compounds
medicine
Vitamin D and neurology
Humans
Thyroid-Stimulating Hormone
Pharmacology
White coat
business.industry
lcsh:R
Body Weight
Biology and Life Sciences
medicine.disease
Hormones
Blood pressure
Endocrinology
People and Places
Linear Models
lcsh:Q
business
Body mass index
Antihypertensives
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0188669 (2017)
ISSN: 1932-6203
Popis: Background: Previous reports about the relationship between a high parathyroid hormone (PTH) and low vitamin D levels with blood pressure in different hypertension groups are conflicting. Objective: We studied serum PTH and vitamin D levels in white-coat (WCHT) and sustained hypertension (SHT) patients who had not been on antihypertensive treatment. We also investigated the association between serum PTH and vitamin D levels with respect to blood pressure in SHT and WCHT patients. Methods: We included 52 SHT patients (54.06 ± 9.2 years, 32 newly diagnosed and 20 previously diagnosed with SHT who had not been treated with antihypertensive medication for 3 months or more), 48 WCHT patients (53.64 ± 9.5 years), and 50 normotensive (NT) healthy controls (53.44 ± 8.4 years) in our study. In addition to routine tests, PTH and vitamin D levels were measured. Results: Serum PTH levels were significantly higher in SHT patients not taking antihypertensive medications than in WCHT patients and NT controls (p = 0.004). Although PTH levels were higher in WCHT than in NT groups, the difference was not statistically significant. In SHT patients, PTH levels showed a positive correlation with office systolic (r = 0.363, p = 0.008), office diastolic (r = 0.282, p = 0.038), home systolic (r = 0.390, p = 0.004), and home diastolic blood pressures (r = 0.397, p = 0.003). Serum vitamin D levels were similar in SHT, WCHT and NT groups. Vitamin D levels were not associated with blood pressures in the entire study group. Furthermore, no significant relation was found between vitamin D and PTH levels in SHT and WCHT groups. Conclusion: PTH levels are significantly higher in untreated SHT patients than WCHT patients and NT subjects. However, vitamin D levels are similar in SHT, WCHT and NT groups. There is a significant association between PTH levels and blood pressures suggesting PTH has a role in increase of blood pressure in SHT. © 2017 Akgül et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Databáze: OpenAIRE
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