Oncogenic and Anti-Oncogenic Effects of Transient Receptor Potential Channels
| Autor: | Sonia Liberati, Giorgio Santoni, Matteo Santoni, Massimo Nabissi, Maria Beatrice Morelli |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
TRPML Chemistry Antineoplastic Agents General Medicine TRPP Bioinformatics TRPV Transient receptor potential channel Transient Receptor Potential Channels TRPM Neoplasms Drug Discovery Biomarkers Tumor Cancer research Animals Humans TRPA Ankyrin Molecular Targeted Therapy RNA Messenger Angiogenesis Apoptosis Target therapy Transient receptor potential channels Tumor promoting proteins Tumor suppressor proteins Drug Discovery3003 Pharmaceutical Science TRPC |
| Zdroj: | Current Topics in Medicinal Chemistry. 13:344-366 |
| ISSN: | 1568-0266 |
| DOI: | 10.2174/1568026611313030011 |
| Popis: | Transient Receptor Potential (TRP) channels affect several inflammatory and neoplastic conditions. About thirty TRPs have been identified to date and divided into seven families: TRPC (Canonical), TRPV (Vanilloid), TRPM (Melastatin), TRPML (Mucolipin), TRPP (Polycystin), and TRPA (Ankyrin transmembrane protein) and TRPN (NomPClike). Among these, the TRPC, TRPM, and TRPV families have been mainly correlated with malignant growth and progression. The aim of this review is to summarize data reported so far on the expression and functional role of TRP channels in different types of cancers. TRP channels have been recently implicated in the triggering of enhanced proliferation, aberrant differentiation, and resistance to apoptotic cell death, leading to uncontrolled tumor growth and progression. Depending on cancer stage, up and down-regulation of TRP mRNAs and protein expression have been reported. These changes have been shown to exhibit cancer promoting (oncogenic) or inhibiting/delaying (tumor suppressor) effects. We are only at the beginning, and more detailed study on the physiopathologic role of TRP channels is required to understand how the deregulation of TRP channel expression and function contributes to tumor development and progression. It is hoped that greater knowledge about TRP biology will enable future development of new chemotherapeutic agents for specific TRP targets, and the use of TRP channels as evaluable markers in diagnostic and/or prognostic analysis. |
| Databáze: | OpenAIRE |
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