Waspergillamide A, a Nitro depsi-Tetrapeptide Diketopiperazine from an Australian Mud Dauber Wasp-Associated Aspergillus sp. (CMB-W031)
| Autor: | Zhuo Shang, Angela A. Salim, Ernest Lacey, Robert J. Capon, Michelle Quezada, Pabasara Kalansuriya |
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| Rok vydání: | 2017 |
| Předmět: |
Stereochemistry
Wasps Pharmaceutical Science Marine Biology Diketopiperazines Fungus 010402 general chemistry 01 natural sciences Indole Alkaloids Analytical Chemistry Mud dauber Nonribosomal peptide Depsipeptides Drug Discovery Animals Nuclear Magnetic Resonance Biomolecular Chemical decomposition Pharmacology chemistry.chemical_classification Aspergillus Molecular Structure biology Tetrapeptide ATP synthase 010405 organic chemistry Organic Chemistry Australia biology.organism_classification 0104 chemical sciences Complementary and alternative medicine chemistry Biochemistry biology.protein Nitro Molecular Medicine |
| Zdroj: | Journal of Natural Products. 80:1192-1195 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.6b01062 |
| Popis: | Chemical profiling of extracts from a mud dauber wasp-associated fungus, Aspergillus sp. (CMB-W031), revealed a remarkably diverse array of secondary metabolites, with many biosynthetic gene clusters being transcriptionally responsive to specific culture conditions. Chemical fractionation of a jasmine rice cultivation yielded many known fungal metabolites, including the highly cytotoxic (-)-stephacidin B and an unprecedented nonribosomal peptide synthase derived nitro depsi-tetrapeptide diketopiperazine, waspergillamide A (1). All structures were assigned by detailed spectroscopic analysis and, where appropriate, chemical degradation and Marfey's analysis. |
| Databáze: | OpenAIRE |
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