ALOX5AP gene and the PDE4D gene in a central European population of stroke patients

Autor: Jakob C. Mueller, Gerhard F. Hamann, Erich Wichmann, Thomas Meitinger, Martin Dichgans, Elin Lõhmussaar, Tõnis Org, Andreas Gschwendtner
Rok vydání: 2005
Předmět:
Male
Linkage disequilibrium
Pathology
Iceland
Linkage Disequilibrium
Gene Frequency
Ischemia
Risk Factors
Odds Ratio
Europe
Eastern
Stroke
Genetics
biology
Middle Aged
Magnetic Resonance Imaging
PDE4D Gene
Regression Analysis
Female
Cardiology and Cardiovascular Medicine
Genetic Markers
Risk
medicine.medical_specialty
Genotype
5-Lipoxygenase-Activating Proteins
Polymorphism
Single Nucleotide
Sex Factors
medicine
Humans
5-lipoxygenase-activating protein
Allele
Allele frequency
Gene
Alleles
Edetic Acid
Aged
Advanced and Specialized Nursing
business.industry
Haplotype
Membrane Proteins
medicine.disease
Cyclic Nucleotide Phosphodiesterases
Type 3
Cyclic Nucleotide Phosphodiesterases
Type 4
Haplotypes
3'
5'-Cyclic-AMP Phosphodiesterases
Case-Control Studies
biology.protein
Neurology (clinical)
business
Carrier Proteins
Microsatellite Repeats
Zdroj: Stroke. 36(4)
ISSN: 1524-4628
Popis: Background and Purpose— Recent evidence has implicated the genes for 5-lipoxygenase activating protein ( ALOX5AP ) and phosphodiesterase 4D ( PDE4D ) as susceptibility genes for stroke in the Icelandic population. The aim of the present study was to explore the role of these genes in a central European population of stroke patients. Methods— A total of 639 consecutive stroke patients and 736 unrelated population-based controls that had been matched for age and sex were examined using a case-control design. Twenty-two single-nucleotide polymorphisms (SNPs) covering ALOX5AP were genotyped. For PDE4D , microsatellite AC008818-1 and 12 SNPs, which tag all common haplotypes in previously identified linkage disequilibrium (LD) blocks, were analyzed. Results— A nominally significant association with stroke was observed with several SNPs from ALOX5AP , including SNP SG13S114, which had been part of the Icelandic at-risk haplotype. Associations were stronger in males than in females, with SG13S114 (odds ratio, 1.24; 95% CI, 1.04 to 1.55; P =0.017) and SG13S100 (odds ratio, 1.26; 95% CI 1.03 to 1.54; P =0.024) showing the strongest associations. No significant associations were detected with single markers and haplotypes in PDE4D . The frequencies of single-marker alleles and haplotypes differed largely from those in the Icelandic population. Conclusions— The present study suggests that sequence variants in the ALOX5AP gene are significantly associated with stroke, particularly in males. Variants in the PDE4D gene are not a major risk factor for stroke in individuals from central Europe. Population differences in allele and haplotype frequencies as well as LD structure may contribute to the observed differences between populations.
Databáze: OpenAIRE
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