Self-Assembled, Biodegradable Magnetic Resonance Imaging Agents: Organic Radical-Functionalized Diblock Copolymers
| Autor: | Hyunjoon Kong, Rudy J. Wojtecki, Ashlynn L. Z. Lee, Artem Shkumatov, Shujun Gao, Yi Yan Yang, Haritz Sardon, Cartney E. Smith, James L. Hedrick, Julian M. W. Chan |
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| Rok vydání: | 2022 |
| Předmět: |
Materials science
Polymers and Plastics Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention Nanomaterials Inorganic Chemistry chemistry.chemical_compound law Amphiphile Materials Chemistry Copolymer Electron paramagnetic resonance chemistry.chemical_classification Organic Chemistry Spin–lattice relaxation Polymer 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences chemistry 0210 nano-technology Ethylene glycol |
| Zdroj: | ACS macro letters. 6(2) |
| ISSN: | 2161-1653 |
| Popis: | We report the design, synthesis, and evaluation of biodegradable amphiphilic poly(ethylene glycol)-b-polycarbonate-based diblock copolymers containing pendant persistent organic radicals (e.g., PROXYL). These paramagnetic radical-functionalized polymers self-assemble into micellar nanoparticles in aqueous media, which preferentially accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect. Through T1 relaxation NMR studies, as well as magnetic resonance imaging (MRI) studies on mice, we show that these nanomaterials are effective as metal-free, biodegradable MRI contrast agents. We also demonstrate anticancer drugs can be readily loaded into the nanoparticles, conferring therapeutic delivery properties in addition to their imaging properties making these materials potential theranostic agents in the treatment of cancer. |
| Databáze: | OpenAIRE |
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