Efficacy of levetiracetam at 12 months in children classified by seizure type, cognitive status, and previous anticonvulsant drug use
| Autor: | Marjorie Bunch, Steven L. Kugler, David E. Mandelbaum, Jan B. Wollack, Anuradha Venkatasubramanian |
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| Rok vydání: | 2005 |
| Předmět: |
Drug
Adult Male Pediatrics medicine.medical_specialty Levetiracetam Adolescent media_common.quotation_subject medicine.medical_treatment Zonisamide Drug Administration Schedule 03 medical and health sciences 0302 clinical medicine Cognition 030225 pediatrics medicine Humans Adverse effect Child media_common Retrospective Studies Dose-Response Relationship Drug business.industry Infant Retrospective cohort study Isoxazoles Piracetam Anticonvulsant Treatment Outcome Pharmacodynamics Anesthesia Concomitant Child Preschool Pediatrics Perinatology and Child Health Anticonvulsants Drug Therapy Combination Epilepsy Generalized Female Neurology (clinical) Epilepsies Partial business 030217 neurology & neurosurgery medicine.drug Follow-Up Studies |
| Zdroj: | Journal of child neurology. 20(7) |
| ISSN: | 0883-0738 |
| Popis: | In a retrospective study of 59 children (ages 9 months to 23 years; mean age 11 years) with intractable epilepsy, seizure frequency was determined before and after 12 months of levetiracetam therapy. Charts were reviewed for seizure type (focal, generalized, or mixed), cognitive function (no special education versus special education), concomitant anticonvulsant medications (range 0—5), and the number of previous anticonvulsant drugs (range 1—12). Good to excellent seizure control (50—100% reduction) was attained in 6 (40%) patients with focal seizures, 16 (55%) patients with generalized seizures, and 8 (61%) patients with mixed seizures; these efficacy rates were not significantly different. The efficacy of levetiracetam was independent of cognitive status. Adverse effects were not associated with higher mean doses. This could be attributable to different rates of metabolism or represent idiosyncratic responses to the medication. Our finding that those children taking the combination of levetiracetam and zonisamide had a significantly worse outcome than those on levetiracetam and a different drug warrants further study, both clinically and from the standpoint of the mechanisms of action of levetiracetam and zonisamide and/or their pharmacodynamic interactions. ( J Child Neurol 2005;20:590—594). |
| Databáze: | OpenAIRE |
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