Post-surgical thyroid ablation with low or high radioiodine activities results in similar outcomes in intermediate risk differentiated thyroid cancer patients

Autor: Cipri Claudia, Furio Pacini, Gabriele Cevenini, Alexandra Theodoropoulou, Ernesto Brianzoni, Valentina Belardini, Fabio Maino, Maria Grazia Castagna, Silvia Memmo
Jazyk: italština
Rok vydání: 2013
Předmět:
Adult
Male
medicine.medical_specialty
Post surgical
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Papillary
Kaplan-Meier Estimate
Adenocarcinoma
Risk Assessment
Dose-Response Relationship
Iodine Radioisotopes
Endocrinology
Risk Factors
hemic and lymphatic diseases
Internal medicine
medicine
Recurrent disease
Humans
Postoperative Period
Thyroid Neoplasms
Adenocarcinoma
Follicular
Aged
Carcinoma
Papillary
Dose-Response Relationship
Radiation
Female
Follow-Up Studies
Lymph Node Excision
Lymphatic Metastasis
Middle Aged
Neoplasm Staging
Remission Induction
Retrospective Studies
Treatment Outcome
Thyroidectomy
Thyroid cancer
Radiation
business.industry
Carcinoma
Follicular
Retrospective cohort study
General Medicine
medicine.disease
THYROID ABLATION
business
Risk assessment
Intermediate risk
Popis: BackgroundIn differentiated thyroid cancer (DTC) patients at intermediate risk of recurrences, no evidences are provided regarding the optimal radioactive iodine (RAI) activity to be administered for post-surgical thyroid ablation.MethodsThis study aimed to evaluate the impact of RAI activities on the outcome of 225 DTC patients classified as intermediate risk, treated with low (1110–1850 MBq) or high RAI activities (≥3700 MBq).ResultsSix to 18 months after ablation, remission was observed in 60.0% of patients treated with low and in 60.0% of those treated with high RAI activities, biochemical disease was found in 18.8% of patients treated with low and in 14.3% of patients treated with high RAI activities, metastatic disease was found in 21.2% of patients treated with low and in 25.7% of patients treated with high RAI activities (P=0.56). At the last follow-up (low activities, median 4.2 years; high activities, median 6.9 years), remission was observed in 76.5% of patients treated with low and in 72.1% of patients treated with high RAI activities, persistent disease was observed in 18.8% of patients treated with low and in 23.5% of patients treated with high RAI activities, recurrent disease was 2.4% in patients treated with low and 2.1% in patients treated with high RAI activities, deaths occurred in 2.4% of patients treated with low and in 2.1% of patients treated with high RAI activities (P=0.87).ConclusionOur study provides the first evidence that in DTC patients at intermediate risk, high RAI activities at ablation have no major advantage over low activities.
Databáze: OpenAIRE
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