The effect of central and systemic injection of the 5-HT1A receptor agonist 8-OHDPAT and the 5-HT1A receptor antagonist WAY100635 on periaqueductal grey-induced defence behaviour
| Autor: | Charles A. Marsden, S. R. G. Beckett |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
030110 physiology 0301 basic medicine Agonist medicine.medical_specialty Pyridines medicine.drug_class Excitatory Amino Acids Central nervous system Stimulation Motor Activity Piperazines 03 medical and health sciences 0302 clinical medicine Escape Reaction Internal medicine medicine Animals Periaqueductal Gray Pharmacology (medical) Homocysteine Microinjection Pharmacology Behavior Animal Chemistry Antagonist Long-term potentiation Rats Serotonin Receptor Agonists Psychiatry and Mental health Endocrinology medicine.anatomical_structure Receptors Serotonin Excitatory postsynaptic potential 5-HT1A receptor Serotonin Antagonists Receptors Serotonin 5-HT1 030217 neurology & neurosurgery |
| Zdroj: | Journal of Psychopharmacology. 11:35-40 |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | The effects of the selective 5-HT1A agonist, 8-hydroxy-2-(di- n-propylamino)-tetralin (8-OHDPAT) and the selective 5-HT1A antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperzinyl]ethyl]-N-(pyridinyl) cyclohexanecarboxa mide trichloride (WAY100635) on periaqueductal grey (PAG)-stimulated defence behaviour were tested in the rat. Microinjection of the excitatory amino acid, D, L-homocysteic acid (DLH) into the dorsal region of the PAG produced overt aversive behaviour characteristic of the defence response, consisting of explosive motor behaviours which were quantified in terms of their duration and the number of arena revolutions and jumps made by the animal. Intra-PAG pre-treatment with 8-OHDPAT (3, 10 and 25 nmol in 250 nl) 10 min before DLH stimulation significantly attenuated the defence behaviour. This could be reversed by peripheral application of WAY100635 (0.1 mg/kg). In contrast, peripheral 8-OHDPAT (0.03, 0.1 and 0.3 mg/kg) produced a significant potentiation of the DLH response which could also be blocked by peripheral WAY100635. When WAY100635 (10 nmol in 250 nl) alone was given into the PAG a significant increase in DLH induced behaviours was observed whereas peripherally applied WAY100635 (0.1 mg/kg) was without effect. These data support previous findings which indicate that serotonergic modulation of aversive behaviours such as defence can be mediated by 5-HT 1A receptors. Furthermore there is evidence to indicate a differential involvement of pre- and post synaptic 5-HT1A receptors. |
| Databáze: | OpenAIRE |
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