Combined Effects and Cross-Interactions of Different Antibiotics and Polypeptides in Salmonella bredeney
| Autor: | Mengjiao Zhu, Zhaoxin Lu, Xiaomei Bie, Xiangyu Ju, Haizhen Zhao, Jinzhi Han |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Drug Salmonella medicine.drug_class media_common.quotation_subject 030106 microbiology Immunology Salmonella Bredeney Antibiotics Population Microbial Sensitivity Tests Biology medicine.disease_cause beta-Lactams Microbiology Public healthcare 03 medical and health sciences Minimum inhibitory concentration Drug Resistance Multiple Bacterial medicine Humans education media_common Pharmacology education.field_of_study Salmonella enterica Drug Synergism Anti-Bacterial Agents Drug Combinations 030104 developmental biology Aminoglycosides Tetracyclines Macrolides Antagonism Peptides Drug Antagonism Fluoroquinolones |
| Zdroj: | Microbial drug resistance (Larchmont, N.Y.). 24(10) |
| ISSN: | 1931-8448 |
| Popis: | Salmonella spp. are health-threatening foodborne pathogens. The increasingly common spread of antibiotic-resistant Salmonella spp. is a major public healthcare issue worldwide. In this study, we wished to explore (1) antibiotic or polypeptide combinations to inhibit multidrug-resistant Salmonella bredeney and (2) the regulation of cross-resistance and collateral sensitivity of antibiotics and polypeptides. We undertook a study to select antibiotic combinations. Then, we promoted drug-resistant strains of S. bredeney after 15 types of antibiotic treatment. From each evolving population, the S. bredeney strain was exposed to a particular single drug. Then, we analyzed how the evolved S. bredeney strains acquired resistance or susceptibility to other drugs. A total of 105 combinations were tested against S. bredeney following the protocols of CLSI-2016 and EUCAST-2017. The synergistic interactions between drug pairings were diverse. Notably, polypeptides were more likely to be linked to synergistic combinations: 56% (19/34) of the synergistic pairings were relevant to polypeptides. Simultaneously, macrolides demonstrated antagonism toward polypeptides. The latter were more frequently related to collateral sensitivity than the other drugs because the other 13 drugs sensitized S. bredeney to polypeptides. In an experimental evolution involving 15 drugs, single drug-evolved strains were examined against the other 14 drugs, and the results were compared with the minimal inhibitory concentration of the ancestral strain. Single drug-evolved S. bredeney strains could alter the sensitivity to other drugs, and S. bredeney evolution against antibiotics could sensitize it to polypeptides. |
| Databáze: | OpenAIRE |
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