Synthesis of DL-Hydroxybenzenamides as Anticonvulsants
| Autor: | Miguel A. Dominguez‐Rodriguez, Liliana Yasutake-Kimoto, Giovanna Gutierrez‐Laflor, Martha Alcala‐Renteria, Meza-Toledo Se, Carvajal-Sandoval G, Javier Peralta-Cruz, Rodrigo Jaime-Rodriguez, Maria G. Nava‐Arzaluz |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Spectrophotometry Infrared Stereochemistry medicine.medical_treatment Convulsants Hydroxylation Ring (chemistry) Mice chemistry.chemical_compound Seizures Drug Discovery medicine Animals Potency Pentylenetetrazol Butyramide Chemistry Biological activity Reference drug Anticonvulsant Benzamides Pentylenetetrazole Anticonvulsants Indicators and Reagents Phenobarbital medicine.drug |
| Zdroj: | Arzneimittelforschung. 58:105-110 |
| ISSN: | 1616-7066 0004-4172 |
| DOI: | 10.1055/s-0031-1296477 |
| Popis: | The anticonvulsant activity of some DL-hydroxybenzenamides is described. The following compounds from this series were prepared and tested: DL-2-hydroxy-2-(3'-bromophenyl)butyramide (4, CAS 620950-12-1), DL-2-hydroxy-2-(4'-bromophenyl)butyramide (5, CAS 620950-13-2), DL-2-hydroxy-2-(3'-nitrophenyl)butyramide (6, CAS 620950-14-3), DL-2-hydroxy-2-phenyl hexanamide (7, CAS 63002-05-1), DL-2-hydroxy-2-(3',4'-dichlorophenyl)hexanamide (8, CAS 863976-06-1), DL-3-hydroxy-3-(4'-bromophenyl)pentanamide (9, CAS 620950-16-5), DL-3-hydroxy-3-phenyl-heptanamide (10, CAS 863976-08-3) and DL-4-hydroxy-4-(4'-bromophenyl)hexanamide (11,CAS 620950-18-7). Compounds 4, 5, 9 and 11 exhibited significant activity in seizures induced by pentylenetetrazol. Incorporation of bromine in the phenyl ring increased their potency. Compounds 4, 5, 9 and 11 exhibited a similar anticonvulsant activity as the reference drug phenobarbital (CAS 50-06-6). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|