Chemical tools for dissecting cell division
| Autor: | Michael A. Lampson, Geng-Yuan Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Cell division Computer science Process (engineering) media_common.quotation_subject Cell Cycle 030302 biochemistry & molecular biology Cell Biology Computational biology Cell cycle Division (mathematics) Article 03 medical and health sciences Genetic Techniques Animals Humans Function (engineering) Molecular Biology Chemical genetics Cell Division 030304 developmental biology media_common |
| Zdroj: | Nat Chem Biol |
| ISSN: | 1552-4469 1552-4450 |
| DOI: | 10.1038/s41589-021-00798-3 |
| Popis: | Components of the cell division machinery typically function at varying cell cycle stages and intracellular locations. To dissect cellular mechanisms during the rapid division process, small-molecule probes act as complementary approaches to genetic manipulations, with advantages of temporal and in some cases spatial control and applicability to multiple model systems. This Review focuses on recent advances in chemical probes and applications to address select questions in cell division. We discuss uses of both enzyme inhibitors and chemical inducers of dimerization, as well as emerging techniques to promote future investigations. Overall, these concepts may open new research directions for applying chemical probes to advance cell biology. This Review summarizes recent progress in small-molecule probes used to address questions in cell division and appraises some emerging techniques that can be adapted to cell division studies. |
| Databáze: | OpenAIRE |
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