Comparison of Cilostazol and Naftidrofuryl in an Experimental Acute Ischemia-Reperfusion Model
| Autor: | Hale Maral Kir, Ömer Faruk Gülaştı, Deniz Sahin, Fatma Ceyla Eraldemir, Ersan Ozbudak, Şadan Yavuz, Ali Ahmet Arıkan |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Nafronyl Myocardial Reperfusion Injury 030204 cardiovascular system & hematology 030230 surgery Kidney Antioxidants Acute ischemia 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Rats Wistar Muscle Skeletal business.industry Vascular disease Brain General Medicine medicine.disease Naftidrofuryl Cilostazol Peripheral Disease Models Animal Oxidative Stress Liver Reperfusion Injury Cardiology Surgery medicine.symptom Cardiology and Cardiovascular Medicine business Claudication Biomarkers medicine.drug |
| Zdroj: | Vascular and endovascular surgery. 55(1) |
| ISSN: | 1938-9116 |
| Popis: | Introduction: Naftidrofuryl and cilostazol are drugs with proven efficacy in the treatment of claudication in peripheral vascular disease. In this experimental study, we evaluated the effects of naftidrofuryl and cilostazol in ischemia-reperfusion (IR) injury on various tissues. Materials and Methods: 40 male albino Wistar rats (8-12 weeks old, 250-350 g.) are randomly divided into 4 groups: Control (Group 1), sham (group 2), cilostazol pre-treatment (group 3), naftidrofuryl pre-treatment (group 4). During 21 days placebo is given to group 2, 12 mg/kg/day cilostazol is given to group 3, 50 mg/kg/day naftidrofuryl is given to group 4 orally. Ischemia and reperfusion are induced at the lower hind limb in Groups 2, 3 and 4. Ischemic muscle, kidney, liver, heart, brain and blood samples are obtained. The total antioxidant capacity, oxidant levels and oxidative stress index are studied for each group. Results: Both drugs have protective effects of remote organ injury following IR. Systemic effects are similar to each other, both have protective effects of IR injury. It showed no statistical significance in the total antioxidant capacity. Total oxidant levels are significantly affected by cilostazol in the heart (p < 0.01) and by naftidrofuryl in the liver (p < 0.01). The effect on oxidative stress was only significant with cilostazol on the heart (p < 0.01). Conclusion: Cilostazol and naftidrofuryl had beneficial effects in all tissues against tissue damage caused by IR injury. In ischemic muscle, kidney and heart cilostazol had improved outcomes comparing to naftidrofuryl. Naftidrofuryl had benefits over cilostazol in liver tissue. |
| Databáze: | OpenAIRE |
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