Diffuse large B-cell lymphoma, not otherwise specified of the palate: A case report
| Autor: | Thaís dos Santos Fontes Pereira, Ricardo Alves Mesquita, Alexandre Fonseca de Castro, Giovanna Ribeiro Souto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Incisional biopsy Prognostic factor Oral Medicine and Pathology Soft palate business.industry Not Otherwise Specified Odontología Case Report CIENCIAS MÉDICAS [UNESCO] medicine.disease Ciencias de la salud World health Lymphoma medicine.anatomical_structure immune system diseases hemic and lymphatic diseases UNESCO::CIENCIAS MÉDICAS medicine Immunohistochemistry business General Dentistry Diffuse large B-cell lymphoma |
| Zdroj: | Journal of Clinical and Experimental Dentistry Souto, Giovanna Ribeiro ; Pereira, Thaís dos Santos Fontes ; Castro, Alexandre Fonseca de ; Mesquita, Ricardo Alves. Diffuse large B-cell lymphoma, not otherwise specified of the palate: a case report. En: Journal of Clinical and Experimental Dentistry, 2013, Vol. 5, No. 5: 287-290 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname |
| ISSN: | 1989-5488 |
| Popis: | Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of non-Hodgkin´s lymphoma found in oral and maxillofacial regions. A large number of cases may be biologically heterogeneous, which are commonly defined as DLBCL, not otherwise specified (NOS) by the World Health Organization (WHO-2008). The present case reports on an ulcer of raised and irregular edges, found on the border between the hard and soft palate, as the first and only manifestation of an extranodal non-Hodgkin lymphoma in an 85-year-old patient. Incisional biopsy was carried out, and the specimen revealed a proliferation of large lymphoid cells suggestive of diffuse large cell lymphoma. An immunohistochemical analysis was performed. EBV-RNA was assessed by in situ hybridization that also proved to be negative. Immunohistochemical and EBV analyses are important to avoid delays and inappropriate treatment strategies. Although advanced age is considered an adverse prognostic factor, early diagnosis did prove to be a key contributory factor in the cure of non-Hodgkin lymphoma. Key words:Diffuse large B-cell lymphoma, elderly, EBV. |
| Databáze: | OpenAIRE |
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