Paclitaxel-induced formation of 3D nanocrystal superlattices within injectable protein-based hybrid nanoparticles

Autor:	Jongnam Park, Ho Yeon Son, Jeong Yu Lee, Jae Chul Park, Yoon Sung Nam
Rok vydání:	2018
Předmět:	Models Molecular Materials science Paclitaxel Cell Survival Superlattice Dispersity Serum albumin Nanoparticle Serum Albumin Human 02 engineering and technology Polyethylene glycol 010402 general chemistry 01 natural sciences Catalysis Injections Polyethylene Glycols chemistry.chemical_compound Neoplasms Materials Chemistry medicine Humans Magnetite Nanoparticles biology Metals and Alloys General Chemistry 021001 nanoscience & nanotechnology Human serum albumin Antineoplastic Agents Phytogenic 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Nanocrystal Chemical engineering Ceramics and Composites biology.protein MCF-7 Cells Nanoparticles 0210 nano-technology medicine.drug HeLa Cells
Zdroj:	Chemical communications (Cambridge, England). 54(82)
ISSN:	1364-548X
Popis:	Self-assembly of monodisperse superparamagnetic iron oxide nanocrystals into a close-packed, three-dimensional (3D) superlattice is designed within cross-linked protein-based nanoparticles composed of human serum albumin and polyethylene glycol. The prepared nanoparticles are very stable in serum and exhibit a high T2 relaxivity as well as anti-cancer activity, indicating the practical benefits of ordering nanocrystals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ea4dcca4ad26003c0c028976a25822 https://pubmed.ncbi.nlm.nih.gov/30264087 Zobrazit plný text záznamu