[Experimental study of the influence of recombinant human lactoferrin on the levels of androgens and basic parameters of lipid and protein metabolism]
| Autor: | V.S. Lukashevich, Yu.A. Rudnichenko, I.V. Zalutsky |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Protein metabolism General Biochemistry Genetics and Molecular Biology law.invention 03 medical and health sciences chemistry.chemical_compound Blood serum law Internal medicine medicine Animals Humans Testosterone 030102 biochemistry & molecular biology biology Estradiol Cholesterol Lactoferrin Lipid metabolism General Medicine Blood Proteins Blood proteins Lipids Recombinant Proteins Rats 030104 developmental biology Endocrinology chemistry Recombinant DNA biology.protein |
| Zdroj: | Biomeditsinskaia khimiia. 62(5) |
| ISSN: | 2310-6972 |
| Popis: | System administration of human recombinant lactoferrin per os to rats for 2,5 months increased serum and testicular levels of total testosterone. The data correlated with the increase in free testosterone levels. These changes were accompanied by an increase of concentrations of steroidogenesis substrates (cholesterol, progesterone, and 17-OH progesterone) and a decrease of the estradiol content in blood serum. This resulted in the 3.6-3.8-fold increase of the testosterone/estradiol index. Basic parameters of lipid and protein were also studied. Results of this study suggest that lactoferrin administration causes activation of androgen synthesis and lipid metabolism.Sistemnoe (v techenie 2,5 mesiatsev) vvedenie per os rekombinantnogo laktoferrina cheloveka per os vyzyvalo povyshenie urovnia obshchego testosterona v syvorotke krovi i gomogenatakh semennikov éksperimental'nykh zhivotnykh, kotoroe korrelirovalo s uvelicheniem svobodnogo testosterona. V syvorotke krovi imelo mesto uvelichenie kontsentratsii substratov steroidogeneza (kholesterina, progesterona i 17-ON progesterona) i snizhenie soderzhaniia éstradiola, chto privodilo k uvelicheniiu testosteron/éstradiolovogo indeksa v 3,6-3,8 raza. Izucheny osnovnye pokazateli lipidnogo i belkovogo obmena. Poluchennye rezul'taty svidetel'stvuiut ob aktivatsii laktoferrinom sinteza androgenov i lipidnogo obmena. |
| Databáze: | OpenAIRE |
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