Microbial metabolites of harman alkaloids
| Autor: | Ikhlas A. Khan, Wimal Herath, Julie Rakel Mikell, Daneel Ferreira |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Magnetic Resonance Spectroscopy
biology Molecular Structure Stereochemistry Chemistry Alkaloid Rhodotorula General Chemistry General Medicine Pharmacognosy Rhodotorula rubra biology.organism_classification Harmaline Tryptamines chemistry.chemical_compound Harmine Cunninghamella Drug Discovery Organic chemistry Harmane Cunninghamella echinulata Harmalol Biotransformation |
| Zdroj: | Chemicalpharmaceutical bulletin. 51(6) |
| ISSN: | 0009-2363 |
| Popis: | Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoethyl)-7-hydroxyindole (4), respectively. Harman (5) was biotransformed by Cunninghamella echinulata NRRL 3655 into 6-hydroxyharman (6) and harman-2-oxide (7). |
| Databáze: | OpenAIRE |
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