Disease Associated with Equine Coronavirus Infection and High Case Fatality Rate
| Autor: | Jamie K. Higgins, E. Scott, S. Mcintosh, Jill C. Higgins, Asli Mete, Federico Giannitti, Nicola Pusterla, C. L. Fielding |
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| Rok vydání: | 2014 |
| Předmět: |
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medicine.medical_specialty Idaho Disease Standard Article Encephalopathy medicine.disease_cause Gastroenterology California Disease Outbreaks Vaccine Related Feces Ammonia Internal medicine Biodefense Epidemiology Case fatality rate medicine Animals Veterinary Sciences Horses Coronavirus Retrospective Studies Infectious disease General Veterinary business.industry Prevention Outbreak Hyperammonemia Viral Load medicine.disease Virology Texas Standard Articles Enteritis Virus Shedding Emerging Infectious Diseases Infectious Diseases Encephalitis Miniature horse Female Horse Diseases business Infection Coronavirus Infections Viral load |
| Zdroj: | Journal of Veterinary Internal Medicine Journal of veterinary internal medicine, vol 29, iss 1 |
| ISSN: | 0891-6640 |
| DOI: | 10.1111/jvim.12480 |
| Popis: | Author(s): Fielding, CL; Higgins, JK; Higgins, JC; McIntosh, S; Scott, E; Giannitti, F; Mete, A; Pusterla, N | Abstract: BackgroundEquine coronavirus (ECoV) is associated with clinical disease in adult horses. Outbreaks are associated with a low case fatality rate and a small number of animals with signs of encephalopathic disease are described.ObjectivesThe aim of this study is to describe the epidemiological and clinical features of two outbreaks of ECoV infection that were associated with an high case fatality rate.Animals14 miniature horses and 1 miniature donkey testing fecal positive for ECoV from two related disease outbreaks.MethodsRetrospective study describing the epidemiological findings, clinicopathological findings, and fecal viral load from affected horses.ResultsIn EcoV positive horses, 27% (4/15) of the animals died or were euthanized. Severe hyperammonemia (677 μmol/L, reference range ≤ 60 μmol/L) was identified in one animal with signs of encephalopathic disease that subsequently died. Fecal viral load (ECoV genome equivalents per gram of feces) was significantly higher in the nonsurvivors compared to animals that survived (P = .02).Conclusions and clinical importanceEquine coronavirus had a higher case fatality rate in this group of miniature horses than previously reported in other outbreaks of varying breeds. Hyperammonemia could contribute to signs of encephalopathic disease, and the fecal viral load might be of prognostic value in affected horses. |
| Databáze: | OpenAIRE |
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