Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis

Autor: A. Lekic, Z. Brekalo, A. Kvesic, M. Kovacevic, Z. Baricev-Novakovic, I. Sutic, A. Bulog, V. Pavisic, I. Mrakovcic-Sutic
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
atherosclerosis
carotid artery stenosis
enzymes matrix metalloproteinases 2 and 9
innate immunity
Tregs
Regulatory T cell
BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Immunology
Immunology
Enzyme-Linked Immunosorbent Assay
Tregs
Biology
Matrix metalloproteinase
T-Lymphocytes
Regulatory
Proinflammatory cytokine
Global Burden of Disease
03 medical and health sciences
chemistry.chemical_compound
Immune system
Immunity
Risk Factors
enzymes matrix metalloproteinases 2 and 9
BIOMEDICINA I ZDRAVSTVO. Javno zdravstvo i zdravstvena zaštita. Obiteljska medicina
medicine
Humans
Carotid Stenosis
BIOMEDICINE AND HEALTHCARE. Public Health and Health Care. Family Medicine
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine
innate immunity
Aged
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina
Aged
80 and over
Innate immune system
Cholesterol
General Medicine
Middle Aged
Flow Cytometry
Lipoproteins
LDL
030104 developmental biology
medicine.anatomical_structure
chemistry
Matrix Metalloproteinase 9
BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Imunologija
Cytokines
Matrix Metalloproteinase 2
Female
Inflammation Mediators
atherosclerosis
Lipoprotein
Protein Binding
Zdroj: Scandinavian journal of immunology
Volume 86
Issue 1
ISSN: 0300-9475
DOI: 10.1111/sji.12563
Popis: Changes in immune and inflammatory responses may play a crucial role in the development and progression of atherosclerosis, as an autoimmune, chronic and progressive inflammatory disease. Immunological activity and vascular inflammation during atherosclerosis can be modulated by autoimmune responses against self-antigens, according to changeable risk factors (cholesterol, oxidized low-density lipoprotein (ox-LDL) in the vascular wall, fatty acids, etc.), and accompanied by accumulation of leucocytes and proinflammatory cytokines, which stimulate the transcription of matrix metalloproteinases (MMPs), whose concentration are increased in foam cell-rich regions. Regulatory T cells (Tregs) represent a unique subpopulation of T cells specialized in the regulation of immune response and in the suppression of proatherogenic T cells. The aim of our study was to examine the interactions between the concentration of enzyme matrix metalloproteinases 2 and 9 (MMP-2 and 9) in urine and the percentage of Tregs in peripheral blood of two groups of patients: with carotid artery stenosis (CAS), undergoing surgery and with mild atherosclerosis (A) from general practice. The method of enzyme immunoassay (ELISA) was used to determine enzyme MMP expression, and Tregs was examined by flow cytometric analysis. Our data have showed a large increase in the enzyme MMP-2 and 9 in the urine of CAS and A patients in comparison with healthy controls and indicated this method as an easy marker for the monitoring of the development of atherosclerosis. Simultaneously, the diminished number of Tregs in the same patients pointed the importance of these regulatory mechanisms in the etiopathogenesis of atherosclerosis and possible Tregs-mediated therapy.
Databáze: OpenAIRE
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