Protective potential of colostrum and early milk against prospective influenza viruses
| Autor: | J. W. M. Lawton, E. K. K. Choi, K. F. Shortridge |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Orthomyxoviridae
Breast milk In ovo medicine.disease_cause fluids and secretions Lactation medicine Humans biology Milk Human business.industry Colostrum food and beverages biology.organism_classification Virology Influenza A virus subtype H5N1 Infectious Diseases medicine.anatomical_structure Pediatrics Perinatology and Child Health Immunology Female Viral disease business Breast feeding |
| Zdroj: | Journal of tropical pediatrics. 36(2) |
| ISSN: | 0142-6338 |
| Popis: | The incidence of infectious disease is markedly reduced in breast-fed infants yet the association of breastfeeding with reduced respiratory illness is less marked even though controlled studies have indicated a protective capability. Non-specific inhibitors (NSI) in colostrum occur naturally and may be atavistic remnants now present in man as natural resistant factors. This study was done to discover if NSI activity for avian influenza viruses (believed by some to be the precursors to pandemic influenza viruses with hemagglutinin subtypes H1 H2 and H3 in humans) occurs in colostrum and early milk. 72 primiparous and multiparous Chinese women who were long term residents of central Hong Kong and had minimal contact with animals were studied. The colostrum and early milk contained varying levels of NSI activity in the hemagglutination inhibition tests but had little viral infectivity neutralizing (VN) activity in ovo assays. 5 of 12 samples lacking detectable NSI did have VN activity and this activity was isolated with the lipid soluble fraction of the breast milk. The ability of colostrum and early milk to neutralize the potentially pandemic H4 influenza subtype emphasizes the variety of protective factors to be found in colostrum and milk and the importance of breastfeeding. |
| Databáze: | OpenAIRE |
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