The antiarrhythmic action of phosphocreatine in acute myocardial ischemia
| Autor: | G.G. Beloshapko, Anna V. Yushmanova, E.P. Anyukhovsky, V.A. Saks, Leonid V. Rosenshtraukh |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Phosphocreatine Ischemia Coronary Disease Biochemistry chemistry.chemical_compound Electrocardiography Dogs Internal medicine medicine Carnivora Animals Sarcolemma biology business.industry Fissipedia Depolarization medicine.disease biology.organism_classification chemistry Ventricular fibrillation Ventricular Fibrillation Cardiology biology.protein Creatine kinase business Anti-Arrhythmia Agents |
| Zdroj: | Biochemical medicine. 34(1) |
| ISSN: | 0006-2944 |
| Popis: | The mechanism of antiarrhythmic action of phosphocreatine on ischemic myocardium was studied by analyses of electrograms from normal and ischemic tissues. Ischemia induced significant changes in amplitude, duration, and conduction time of the electrograms, thereby showing depolarization of membranes and retarded conduction of excitation. Phosphocreatine administered in a single dose, 300 mg/kg iv, completely eliminated ventricular fibrillations in the ischemic hearts and significantly diminished the electrical instability occurring during reperfusion. The effects of phosphocreatine were completely reproduced by its structural analog phosphocreatinine which is inactive in the creatine kinase reaction. It is concluded that the antiarrhythmic effect of both compounds is related to their specific chemical structure and that their specific effect is likely to be mediated via interaction with a sarcolemma site. |
| Databáze: | OpenAIRE |
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