Epiphyseal ewing sarcoma: first reported case with molecular confirmation
| Autor: | Elena García-Esparza, Daniel Azorín, Esther Conde, Yosmar Pérez-González |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent Oncogene Proteins Fusion Bone Neoplasms Sarcoma Ewing Pathology and Forensic Medicine Malignant Bone Neoplasm medicine Humans Oncogene Fusion In Situ Hybridization Fluorescence medicine.diagnostic_test Tibia business.industry Reverse Transcriptase Polymerase Chain Reaction Neural crest RNA-Binding Proteins Magnetic resonance imaging medicine.disease Immunohistochemistry Magnetic Resonance Imaging medicine.anatomical_structure Epiphysis Primitive neuroectodermal tumor Osteosarcoma Surgery Calmodulin-Binding Proteins Sarcoma Anatomy RNA-Binding Protein EWS business Epiphyses |
| Zdroj: | International journal of surgical pathology. 21(2) |
| ISSN: | 1940-2465 |
| Popis: | Ewing sarcoma is the second most common pediatric malignant bone neoplasm after osteosarcoma. Ewing sarcoma comprises “small, round, blue-cell” tumors thought to arise from neural crest cells. The authors report the case of a 14-year-old boy that presented with a nonpainful circumscribed lesion. The radiographs showed a lytic lesion at the tibial epiphysis with a large soft tissue mass, best depicted in the magnetic resonance imaging scan that suggested an aggressive lesion. A needle biopsy of the lesion was performed. The diagnosis of Ewing sarcoma was made based on microscopic, immunohistochemical, polymerase chain reaction, and fluorescence in situ hybridization. This is the third case report about a primary epiphyseal Ewing sarcoma and the fist one with molecular confirmation. |
| Databáze: | OpenAIRE |
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