Effective angiogenesis requires regulation of phosphoinositide signaling
| Autor: | Kai Qin Le, Rajendra Gurung, Elizabeth M Davies, Christina Anne Mitchell |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Endosome Angiogenesis Neovascularization Physiologic 03 medical and health sciences chemistry.chemical_compound Phosphatidylinositol 3-Kinases 0302 clinical medicine Phosphatidylinositol Phosphates Genetics PTEN Animals Humans Phosphatidylinositol Molecular Biology Protein kinase B PI3K/AKT/mTOR pathway Sprouting angiogenesis biology Forkhead Transcription Factors Embryonic stem cell Cell biology 030104 developmental biology chemistry 030220 oncology & carcinogenesis biology.protein Molecular Medicine Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | Advances in biological regulation. 71 |
| ISSN: | 2212-4934 |
| Popis: | Phosphoinositide signaling regulates numerous downstream effectors that mediate cellular processes which influence cell cycle progression, migration, proliferation, growth, survival, metabolism and vesicular trafficking. A prominent role for phosphoinositide 3-kinase, which generates phosphatidylinositol 3,4,5-trisphosphate, a phospholipid that activates a plethora of effectors including AKT and FOXO during embryonic and postnatal angiogenesis, has been described. In addition, phosphatidylinositol 3-phosphate signaling is required for endosomal trafficking, which contributes to vascular remodeling. This review will examine the role phosphoinositide signaling plays in the endothelium and its contribution to sprouting angiogenesis. |
| Databáze: | OpenAIRE |
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