Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch

Autor: Adriana Laura Burgueño, Melisa F. Mensegue, Mariana Lorena Tellechea
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Aortic arch
Male
Taurine
Physiology
Aorta
Thoracic
Blood Pressure
Rats
Inbred WKY
chemistry.chemical_compound
TAURINE
0302 clinical medicine
Pregnancy
Rats
Inbred SHR
TAURINA
Medicine
SPONTANEOUSLY HYPERTENSIVE RATS
ATP synthase
biology
OXIDO NITRICO
ENDOTHELIAL NITRIC OXIDE SYNTHASE
030220 oncology & carcinogenesis
Prenatal Exposure Delayed Effects
Female
purl.org/becyt/ford/3 [https]
Essential Hypertension
Signal Transduction
medicine.medical_specialty
Nitric Oxide Synthase Type III
Down-Regulation
Gestational Age
03 medical and health sciences
purl.org/becyt/ford/3.3 [https]
Sex Factors
Physiology (medical)
medicine.artery
Internal medicine
Animals
Lactation
Fetal programming
Antihypertensive Agents
HIPERTENSION
Pharmacology
Endothelial nitric oxide synthase
HYPERTENSION
business.industry
FETAL PROGRAMMING
Disease Models
Animal
030104 developmental biology
Endocrinology
chemistry
TELOMERE LENGTH
biology.protein
business
Zdroj: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Clinical and Experimental Pharmacology and Physiology. 2020, 45(5)
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
DOI: 10.1111/1440-1681.13260
Popis: Fil: Mensegue, Melisa F. University of Buenos Aires. Institute of Medical Research A. Lanari; Argentina Fil: Mensegue, Melisa F. National Scientific and Technical Research Council. Institute of Medical Research (IDIM). Department of Molecular Genetics and Biology of Complex Diseases; Argentina Fil: Burgueño, Adriana. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Burgueño, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Tellechea, Mariana L. University of Buenos Aires. Institute of Medical Research A. Lanari; Argentina Fil: Tellechea, Mariana L. National Scientific and Technical Research Council. Institute of Medical Research (IDIM). Department of Molecular Genetics and Biology of Complex Diseases; Argentina Fil: Tellechea, Mariana L. Hospital de Niños Ricardo Gutiérrez. Centro de Investigaciones Endocrinológicas Dr. César Bergadá. División de Endocrinología; Argentina Abstract: Essential hypertension is considered to be a result of the interaction between genetic and environmental factors, including perinatal factors. Different advantageous perinatal factors proved to have beneficial long-lasting effects against an abnormal genetic background. Taurine is a ubiquitous sulphur-containing amino acid present in foods such as seafood. The antihypertensive effects of taurine have been reported in experimental studies and in human hypertension. We aimed to investigate the effects of perinatal treatment with taurine in spontaneously hypertensive rats (SHR), a known model of genetic hypertension. Female SHR were administered with taurine (3 g/L) during gestation and lactation (SHR-TAU). Untreated SHR and Wistar-Kyoto rats (WKY) were used as controls. Long-lasting effects in offspring were investigated. Addition of taurine to the mother's drinking water reduced blood pressure in adult offspring. No differences were observed in cardiac hypertrophy. Findings on morphometric evaluations suggest that perinatal treatment with taurine would be partially effective in improving structural alterations of the aorta. Modifications in gene expression of Bcl-2 family members and upregulation of endothelial nitric oxide synthase in the aorta of 22-week-old male offspring were found. No differences were observed on relative telomere length in different cardiovascular tissues between SHR and SHR-TAU. Altogether results suggest that taurine programming, albeit sex specific, is associated with gene expression changes which ultimately may lead to improvement of aortic remodelling and enhanced endothelial function because of augmented nitric oxide (NO) production.
Databáze: OpenAIRE
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