Sex differences in fear discrimination do not manifest as differences in conditioned inhibition
| Autor: | Allison R. Foilb, John P. Christianson, Julia Bals, Mary C. Sarlitto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Cognitive Neuroscience Conditioned inhibition Brief Communication Generalization Psychological Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Discrimination Psychological Generalization (learning) Conditioning Psychological Medicine Animals Psychological testing Discrimination learning Freezing Reaction Cataleptic Analysis of Variance Electroshock Psychological Tests Sex Characteristics Recall business.industry Fear Sprague dawley Inhibition Psychological 030104 developmental biology Neuropsychology and Physiological Psychology Mental Recall Female Analysis of variance Cues business 030217 neurology & neurosurgery Sex characteristics Clinical psychology |
| Popis: | Distinguishing safety from danger is necessary for survival, but is aberrant in individuals with post-traumatic stress disorder (PTSD). While PTSD is more prevalent in women than men, research on sex differences in safety learning is limited. Here, female rats demonstrated greater fear discrimination than males in a CS+/CS− paradigm. To determine if this sex difference transferred to fear inhibition, rats were tested for conditioned inhibition in a summation test with the CS+ and CS− presented in compound; no sex difference emerged. The results suggest sex differences in the neural mechanisms of discrimination learning but not recall of a fear inhibitor. |
| Databáze: | OpenAIRE |
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