Observational study of skin and soft-tissue Staphylococcus aureus infection in patients infected with HIV-1 and epidemics of Panton–Valentine leucocidin-positive community-acquired MRSA infection in Osaka, Japan
| Autor: | Takuma Shirasaka, Yasuharu Nishida, Daisuke Sakanashi, Takahiro Taguri, Tomoko Uehira, Hiroshige Mikamo, Yusuke Koizumi, Mami Takeda, Dai Watanabe, Kazuyuki Hirota, Kentaro Ozawa, Takashi Ueji |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Methicillin-Resistant Staphylococcus aureus 0301 basic medicine Microbiology (medical) Staphylococcus aureus medicine.medical_specialty 030106 microbiology Human immunodeficiency virus (HIV) Exotoxins medicine.disease_cause Sexual and Gender Minorities 03 medical and health sciences 0302 clinical medicine Japan Leukocidins Internal medicine Epidemiology medicine Humans Pharmacology (medical) In patient 030212 general & internal medicine Homosexuality Male Epidemics Retrospective Studies business.industry SCCmec Soft tissue Staphylococcal Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses Community-Acquired Infections Infectious Diseases Panton valentine leucocidin HIV-1 Observational study business |
| Zdroj: | Journal of Infection and Chemotherapy. 26:1254-1259 |
| ISSN: | 1341-321X |
| DOI: | 10.1016/j.jiac.2020.07.007 |
| Popis: | In patients infected with human immunodeficiency virus (HIV)-1 at our hospital, we observed increases in skin and soft-tissue infections (SSTIs) by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Therefore, we analyzed factors related to CA-MRSA infection and performed a molecular epidemiological investigation.HIV-1-infected patients were diagnosed with SSTIs related to S. aureus between 2007 and 2017, and MRSA was classified into community and hospital-acquired types according to published criteria. Information was collected retrospectively from clinical records, and multivariate analysis by logistic regression was performed concerning factors related to CA-MRSA infection. We evaluated the staphylococcal cassette chromosome mec (SCCmec) type, multilocus sequence type, and the presence of genes encoding Panton-Valentine leucocidin (PVL) in 27 MRSA samples isolated during and after 2015.We found 218 episodes of SSTIs in 169 patients, and among initial episodes of SSTIs, the MRSA ratio was higher from 2015 to 2017 relative to that from 2007 to 2014 (88% vs. 44%; p 0.0001). Multivariate analysis showed that in men having sex with men [MSM; odds ratio (OR): 13] and exhibiting onset during and after 2015 (OR: 5.4), CD4These data describe an increased prevalence of SSTIs due to PVL-positive ST8-MRSA-IV, not previously considered epidemic in Japan, in MSM infected with HIV-1 in Osaka, Japan. |
| Databáze: | OpenAIRE |
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