Circovirus in Tissues of Dogs with Vasculitis and Hemorrhage
| Autor: | Sabrina McGraw, Eric Delwart, Stanley L. Marks, Patricia M. Gaffney, Christian M. Leutenegger, Patricia A. Pesavento, Chunlin Wang, Kevin W. Zhu, Linlin Li, Florante N. Dela Cruz, Steven V. Kubiski |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology dogs Epidemiology lcsh:Medicine Polymerase Chain Reaction California 0403 veterinary science Feces Dog Diseases Fever of unknown origin In Situ Hybridization Phylogeny 0303 health sciences hemorrhagic gastroenteritis biology necrotizing vasculitis granulomatous lymphadenitis Hemorrhagic gastroenteritis 04 agricultural and veterinary sciences 3. Good health Diarrhea Infectious Diseases Liver Female medicine.symptom Vasculitis Gastrointestinal Hemorrhage Microbiology (medical) Circovirus medicine.medical_specialty canine vascular disease 040301 veterinary sciences Genome Viral Neutropenia lcsh:Infectious and parasitic diseases 03 medical and health sciences deep sequencing Necrotizing Vasculitis medicine Animals Humans lcsh:RC109-216 viruses Circoviridae Infections Tropism 030304 developmental biology Research lcsh:R medicine.disease biology.organism_classification Virology DNA Viral Lymph Nodes Spleen |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 19, Iss 4, Pp 534-541 (2013) |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | We characterized the complete genome of a novel dog circovirus (DogCV) from the liver of a dog with severe hemorrhagic gastroenteritis, vasculitis, and granulomatous lymphadenitis. DogCV was detected by PCR in fecal samples from 19/168 (11.3%) dogs with diarrhea and 14/204 (6.9%) healthy dogs and in blood from 19/409 (3.3%) of dogs with thrombocytopenia and neutropenia, fever of unknown origin, or past tick bite. Co-infection with other canine pathogens was detected for 13/19 (68%) DogCV-positive dogs with diarrhea. DogCV capsid proteins from different dogs varied by up to 8%. In situ hybridization and transmission electron microscopy detected DogCV in the lymph nodes and spleens of 4 dogs with vascular compromise and histiocytic inflammation. The detection of a circovirus in tissues of dogs expands the known tropism of these viruses to a second mammalian host. Our results indicate that circovirus, alone or in co-infection with other pathogens, might contribute to illness and death in dogs. |
| Databáze: | OpenAIRE |
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