Progressive ultrastructural damage and thickening of the basement membrane of the retinal pigment epithelium in spontaneously diabetic BB rats
| Autor: | Stephen H. Blaydes, Estelle E. May, Peter A. Campochiaro, S. A. Vinores |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Pathology
medicine.medical_specialty Aging Vacuole Biology Basement Membrane Retina Cellular and Molecular Neuroscience chemistry.chemical_compound medicine Diabetes Mellitus Animals Pigment Epithelium of Eye Basement membrane Retinal pigment epithelium Choroid Retinal Vessels Retinal Rats Inbred Strains Diabetic retinopathy Anatomy medicine.disease Sensory Systems Rats Ophthalmology Microscopy Electron medicine.anatomical_structure chemistry Vacuoles Ultrastructure sense organs Retinopathy |
| Zdroj: | Experimental eye research. 46(4) |
| ISSN: | 0014-4835 |
| Popis: | Ultrastructural examination of the neural retina and retinal pigment epithelium was performed in spontaneously diabetic BB rats and non-diabetic littermate controls at various time points during the course of diabetes. Four types of progressive changes occur in diabetic rats: (1) There is a progressive thickening of the basal laminae of the retinal pigment epithelium and the retinal capillaries. (2) In addition to this thickening, there is a progressive, often focal, thickening of the rest of Bruch's membrane, and by 11 1/2 months it contains numerous randomly oriented collagen fibrils. (3) There are progressive ultrastructural changes in retinal pigment epithelial cells consisting of marked dilation of the basal infoldings, the formation of large vacuoles and cell swelling. (4) Rare degenerative changes were noted in retinal capillary pericytes. Since non-diabetic littermates do not show comparable changes, it is likely that they are diabetes-related, suggesting that progressive damage to the retinal pigment epithelium may occur during the course of diabetes. |
| Databáze: | OpenAIRE |
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