Glycosaminoglycan Content of the Lateral Compartment Cartilage in Knees Conforming to the Indications for Oxford Medial Unicompartmental Knee Arthroplasty
| Autor: | Ran Yan, Ju'an Yue, Lu-Yao Ma, Fuyin Wan, Qidong Zhang, Liming Cheng, Wanshou Guo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cartilage
Articular Male medicine.medical_treatment lcsh:Medicine Osteoarthritis Body Mass Index Glycosaminoglycan 03 medical and health sciences 0302 clinical medicine medicine Humans Arthroplasty Replacement Knee Compartment (pharmacokinetics) Unicompartmental knee arthroplasty Aged Glycosaminoglycans 030203 arthritis & rheumatology 030222 orthopedics medicine.diagnostic_test business.industry Unicompartmental Knee Arthroplasty Cartilage lcsh:R Significant difference Magnetic resonance imaging General Medicine Middle Aged Osteoarthritis Knee medicine.disease Arthroplasty medicine.anatomical_structure Female Original Article business Nuclear medicine |
| Zdroj: | Chinese Medical Journal, Vol 131, Iss 2, Pp 194-199 (2018) Chinese Medical Journal |
| ISSN: | 0366-6999 |
| DOI: | 10.4103/0366-6999.222321 |
| Popis: | Background: The quality of the lateral compartment cartilage is important to preoperative evaluation and prognostic prediction of unicompartmental knee arthroplasty (UKA). Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) enables noninvasive assessment of glycosaminoglycan (GAG) content in cartilage. This study aimed to determine the GAG content of the lateral compartment cartilage in knees scheduled to undergo Oxford medial UKA. Methods: From December 2016 to May 2017, twenty patients (20 osteoarthritic knees) conforming to the indications for Oxford medial UKA were included as the osteoarthritis (OA) group, and 20 healthy volunteers (20 knees) paired by sex, knee side, age (±3 years), and body mass index (BMI) (±3 kg/m2) were included as the control group. The GAG contents of the weight-bearing femoral cartilage (wbFC), the posterior non-weight-bearing femoral cartilage (pFC), the lateral femoral cartilage (FC), and tibial cartilage (TC) were detected using dGEMRIC. The dGEMRIC indices (T1Gd) were calculated in the middle three consecutive slices of the lateral compartment. Paired t-tests were used to compare the T1Gd in each region of interest between the OA group and control group. Results: The average age and BMI in the two groups were similar. In the OA group, T1Gd of FC and TC was 386.7 ± 50.7 ms and 429.6 ± 59.9 ms, respectively. In the control group, T1Gd of FC and TC was 397.5 ± 52.3 ms and 448.6 ± 62.5 ms, respectively. The respective T1Gd of wbFC and pFC was 380.0 ± 47.8 ms and 391.0 ± 66.3 ms in the OA group and 400.3 ± 51.5 ms and 393.6 ± 57.9 ms in the control group. Although the T1Gd of wbFC and TC tended to be lower in the OA group than the control group, there was no significant difference between groups in the T1Gd in any of the analyzed cartilage regions (P value of wbFC, pFC, FC, and TC was 0.236, 0.857, 0.465, and 0.324, respectively). Conclusions: The GAG content of the lateral compartment cartilage in knees conforming to indications for Oxford medial UKA is similar with those of age- and BMI-matched participants without OA. Key words: Cartilage; Glycosaminoglycan; Unicompartmental Knee Arthroplasty |
| Databáze: | OpenAIRE |
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