Knowledge, attitudes and behavior of physicians regarding predictive genetic tests for breast and colorectal cancer

Autor: Carolina Marzuillo, Paolo Villari, Maddalena D'Addario, Corrado De Vito, Paola Santini, Elvira D’Andrea, Antonio Boccia, Stefania Boccia
Rok vydání: 2013
Předmět:
Adult
Male
medicine.medical_specialty
Attitude of Health Personnel
Colorectal cancer
Cross-sectional study
Epidemiology
Professional behavior
Adenomatous Polyposis Coli Protein
Breast Neoplasms
Cancer predictive genetic tests
Logistic regression
Odds
Surveys and Questionnaires
Physicians
medicine
Humans
Genetic Predisposition to Disease
Genetic Testing
Settore MED/42 - IGIENE GENERALE E APPLICATA
Genetic testing
BRCA2 Protein
Response rate (survey)
medicine.diagnostic_test
BRCA1 Protein
business.industry
Health Policy
Public Health
Environmental and Occupational Health
professional behavior
knowledge
physicians
cross-sectional survey
cancer predictive genetic tests
attitudes
Middle Aged
medicine.disease
Confidence interval
Cross-Sectional Studies
Knowledge
Italy
Family medicine
Attitudes
Cross-sectional survey
Utilization Review
Female
Colorectal Neoplasms
business
Zdroj: Preventive Medicine. 57(5):477-482
ISSN: 0091-7435
DOI: 10.1016/j.ypmed.2013.06.022
Popis: Background Genetic testing for cancer susceptibility is an emerging technology in medicine. This study assessed the knowledge, attitudes and professional behavior of Italian physicians regarding the use of predictive genetic tests for breast and colorectal cancer, including the BRCA1/2 and APC tests. Methods A cross-sectional survey of a random sample of Italian physicians was performed in 2010 through a self-administered questionnaire. Results A response rate of 69.6% (1079 questionnaires) was achieved. A significant lack of knowledge was detected, particularly for APC testing. Less than half of the physicians agreed on the importance of efficacy and cost-effectiveness evidence in the selection of predictive genetic tests to be offered to the patients. Multiple logistic regression analyses showed that education had a positive influence on knowledge, attitudes and, to a lesser extent, professional use. The factor most strongly related to the physicians' use of genetic testing was patients requests for breast (odds ratio = 12.65; 95% confidence interval 7.77–20.59) or colorectal cancer tests (odds ratio = 7.02; 95% confidence interval 3.61–13.64). A high level of interest for specific training was reported by almost all physicians surveyed. Conclusions Targeted educational programs are needed to improve the expertise of physicians, and, ultimately, to enhance the appropriate use of genetic tests in clinical practice.
Databáze: OpenAIRE
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