Melanoma induction in a hairless mouse with short-term application of dimethylbenz[ a]anthracene
| Autor: | Rosalie Elenitsas, Kligman Lh |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Cancer Research
Lung Neoplasms Skin Neoplasms Time Factors 9 10-Dimethyl-1 2-benzanthracene Melanoma Experimental DMBA Dermatology Guinea pig Mice chemistry.chemical_compound Animals Medicine Croton oil skin and connective tissue diseases neoplasms Mice Hairless Anthracene business.industry Melanoma medicine.disease Hairless Oncology chemistry Lymphatic Metastasis Carcinogens Cancer research Female Human melanoma Lymph business |
| Zdroj: | Melanoma Research. 11:319-324 |
| ISSN: | 0960-8931 |
| Popis: | Melanomas have been induced in hamsters and guinea pigs with short-term, low dose applications of dimethylbenz [a]anthracene (DMBA) alone. In mice, however, melanoma induction has required either croton oil or ultraviolet radiation promotion in addition to DMBA. In this study, we report the development of a malignant melanoma, with metastases, in a hairless mouse after six applications of 0.25% DMBA alone. At sacrifice, a large primary tumour with characteristics of intralesional transformation was present, along with numerous pigmented macules and papules. Metastases were present in lymph nodes and lungs. There was a marked similarity between this melanoma and its precursor lesions and those seen in an earlier, Weiser-Maple guinea pig model, which, in turn, resembled human melanoma. |
| Databáze: | OpenAIRE |
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