Non-steroidal anti-inflammatory drugs antagonise the constipating effects of tramadol
| Autor: | Eulalia Planas, Margarita M. Puig, Asunción Romero, Raquel Poveda, Silvia Sánchez |
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| Rok vydání: | 2003 |
| Předmět: |
Drug
Male media_common.quotation_subject Analgesic Pharmacology Rats Sprague-Dawley medicine Animals Drug Interactions Gastrointestinal Transit Tramadol media_common Dose-Response Relationship Drug business.industry Stomach Anti-Inflammatory Agents Non-Steroidal Ibuprofen Rats Dose–response relationship medicine.anatomical_structure Morphine Antagonism business Constipation medicine.drug |
| Zdroj: | European journal of pharmacology. 482(1-3) |
| ISSN: | 0014-2999 |
| Popis: | We report an antagonistic interaction between tramadol and non-steroidal anti-inflammatory drugs (NSAIDs), on gastrointestinal transit in rats. Transit was evaluated with charcoal and results are expressed as %inhibition. Tramadol and morphine had ED(50)s of 120.70+/-9.54 and 3.20+/-0.26 mg/kg, respectively, while metamizol (85 mg/kg), paracetamol (100 mg/kg) or ibuprofen (50 mg/kg) had no effect. All combinations of tramadol plus an NSAID, resulted in a rightward, non-parallel shift of the curves, which showed (two-way analysis of variance, ANOVA) significant differences from tramadol alone for the dose (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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