Computational design strategy: an approach to enhancing the transdermal delivery of optimal capsaicin-loaded transinvasomes
| Autor: | Tassanan Nimcharoenwan, Nutcha Chomya, Tanasait Ngawhirunpat, Natthaporn Locharoenrat, Sureewan Duangjit |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Diethanolamine
Materials science Chemistry Pharmaceutical Skin Absorption Pharmaceutical Science 02 engineering and technology Skin permeability Administration Cutaneous 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Delivery Systems Organ Culture Techniques Drug Discovery Computer software Zeta potential Computational design Animals Elapidae Transdermal Pharmacology Liposome Chromatography Organic Chemistry Antipruritics 021001 nanoscience & nanotechnology chemistry Capsaicin Drug Design Liposomes 0210 nano-technology Biomedical engineering |
| Zdroj: | Drug development and industrial pharmacy. 43(1) |
| ISSN: | 1520-5762 |
| Popis: | The aim of this study was to design and develop simultaneous optimal transinvasome formulations (OTV) to enhance the transdermal delivery of capsaicin. Using a central composite experimental design with duplicate centroids, 10 model formulations of transinvasomes (TVs) were demonstrated. The lipid compositions of the TV formulations were determined as formulation factors (Xn) and response variables (Yn), respectively. TV formulations containing a constant concentration of phosphatidylcholine, cholesterol, 0.15% capsaicin, and various percentages of d-limonene (X1) and cocamide diethanolamine (X2) were prepared. The physicochemical characteristics, e.g. the vesicle size, size distribution, zeta potential, entrapment efficiency, and skin permeability, of the TV formulations were experimentally investigated. The relationship among the formulation factor, the response variables, and the OTV was predicted using Design Expert® software. The accuracy and reliability of the OTV predicted using computer software were experimentally confirmed and investigated as an experimental transinvasome formulation (ETV). The results indicated that the skin permeability of the ETV was close to the OTV and was significantly higher than that of conventional liposomes and commercial products. The response surfaces estimated by the computer software were helpful in understanding the complicated relationship among the formulation factor, the response variables, and the stability of the TV formulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|