Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes
| Autor: | C. Andrew Combs, Michael Gravett, Thomas J. Garite, Durlin E. Hickok, Jodi Lapidus, Richard Porreco, Julie Rael, Thomas Grove, Terry K. Morgan, William Clewell, Hugh Miller, David Luthy, Leonardo Pereira, Michael Nageotte, Peter A. Robilio, Stephen Fortunato, Hyagriv Simhan, Jason K. Baxter, Erol Amon, Albert Franco, Kenneth Trofatter, Kent Heyborne |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Amniotic fluid Preterm labor Inflammation Chorioamnionitis Gastroenterology DNA Ribosomal Polymerase Chain Reaction Obstetric Labor Premature Pregnancy Risk Factors Internal medicine Medicine Humans Colonization business.industry Interleukin-6 Pregnancy Outcome Obstetrics and Gynecology Intact membranes medicine.disease Amniotic Fluid Logistic Models Immunology Female medicine.symptom business Amniotic cavity |
| Zdroj: | American journal of obstetrics and gynecology. 210(2) |
| ISSN: | 1097-6868 |
| Popis: | The purpose of this study was to compare intraamniotic inflammation vs microbial invasion of the amniotic cavity (MIAC) as predictors of adverse outcome in preterm labor with intact membranes.Interleukin-6 (IL-6) was measured in prospectively collected amniotic fluid from 305 women with preterm labor. MIAC was defined by amniotic fluid culture and/or detection of microbial 16S ribosomal DNA. Cases were categorized into 5 groups: infection (MIAC; IL-6, ≥11.3 ng/mL); severe inflammation (no MIAC; IL-6, ≥11.3 ng/mL); mild inflammation (no MIAC; IL-6, 2.6-11.2 ng/mL); colonization (MIAC; IL-6,2.6 ng/mL); negative (no MIAC; IL-6,2.6 ng/mL).The infection (n = 27) and severe inflammation (n = 36) groups had similar latency (median,1 day and 2 days, respectively) and similar rates of composite perinatal morbidity and mortality (81% and 72%, respectively). The colonization (n = 4) and negative (n = 195) groups had similar outcomes (median latency, 23.5 and 25 days; composite morbidity and mortality rates, 21% and 25%, respectively). The mild inflammation (n = 47) groups had outcomes that were intermediate to the severe inflammation and negative groups (median latency, 7 days; composite morbidity and mortality rates, 53%). In logistic regression adjusting for gestational age at enrollment, IL-6 ≥11.3 and 2.6-11.2 ng/mL, but not MIAC, were associated significantly with composite morbidity and mortality rates (odds ratio [OR], 4.9; 95% confidence interval [CI], 2.2-11.2, OR, 3.1; 95% CI, 1.5-6.4, and OR, 1.8; 95% CI, 0.6-5.5, respectively).We confirmed previous reports that intraamniotic inflammation is associated with adverse perinatal outcomes whether or not intraamniotic microbes are detected. Colonization without inflammation appears relatively benign. Intraamniotic inflammation is not simply present or absent but also has degrees of severity that correlate with adverse outcomes. We propose the designation amniotic inflammatory response syndrome to denote the adverse outcomes that are associated with intraamniotic inflammation. |
| Databáze: | OpenAIRE |
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