A Single Gene Target of an ETS-Family Transcription Factor Determines Neuronal CO2-Chemosensitivity
| Autor: | Niels Ringstad, Luis A. Martinez-Velazquez, Vaida Juozaityte, Roger Pocock, Julia P. Brandt, Sonya Aziz-Zaman, Jakob Gramstrup Petersen |
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| Rok vydání: | 2012 |
| Předmět: |
lcsh:Medicine
medicine.disease_cause 0302 clinical medicine Molecular Cell Biology Gene expression lcsh:Science Caenorhabditis elegans Neurons Regulation of gene expression Genetics 0303 health sciences Mutation Multidisciplinary Behavior Animal biology Animal Models Cell biology Research Article Plasmids Sensory Receptor Cells Molecular Genetics 03 medical and health sciences Model Organisms medicine Animals Gene family Binding site Caenorhabditis elegans Proteins Biology Transcription factor Alleles 030304 developmental biology Binding Sites Proto-Oncogene Proteins c-ets lcsh:R Computational Biology Carbon Dioxide biology.organism_classification Gene Expression Regulation Microscopy Fluorescence Receptors Guanylate Cyclase-Coupled nervous system Guanylate Cyclase lcsh:Q Gene Deletion 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, Vol 7, Iss 3, p e34014 (2012) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0034014 |
| Popis: | Many animals possess neurons specialized for the detection of carbon dioxide (CO(2)), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO(2) is poorly understood. We report here a mechanism that endows C. elegans neurons with the ability to detect CO(2). The ETS-5 transcription factor is necessary for the specification of CO(2)-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons. Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO(2)-sensing neurons in other phyla. |
| Databáze: | OpenAIRE |
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