Spatial confinement instigates environmental determination of neuronal polarity

Autor: Joshua A. Maurer, Dawn M. Johnson, Jad P. Abi-Mansour
Rok vydání: 2012
Předmět:
Zdroj: Integrative Biology. 4:1034-1037
ISSN: 1757-9708
DOI: 10.1039/c2ib20126g
Popis: Here we used patterned self-assembled monolayer (SAM) chemistry to explore the role of spatial confinement on the growth and proliferation of a developing neuron. Despite extensive previous work on the molecular mechanisms controlling these processes, classical biological approaches have not been able to clearly distinguish whether differentiation is predetermined or environmentally determined.
Databáze: OpenAIRE