Ibuprofen in the treatment of postoperative pain in small children. A randomized double-blindplacebo controlled parallel group study
| Autor: | J Vainio, E L Maunuksela, L. Nuutinen, Hannu Kokki, H. Hendolin |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Randomization Vomiting Analgesic Blood Pressure Ibuprofen Placebo Anesthesia Spinal Injections Intramuscular law.invention Placebos Double-Blind Method Randomized controlled trial Administration Rectal Heart Rate law Humans Medicine Elective surgery Pain Measurement Pain Postoperative Morphine business.industry organic chemicals Infant Nausea General Medicine Analgesics Non-Narcotic Surgery Anesthesiology and Pain Medicine Child Preschool Anesthesia Rectal administration Female business medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 38:467-472 |
| ISSN: | 0001-5172 |
| Popis: | The efficacy of ibuprofen as a pre-emptive analgesic for postoperative pain was investigated in 81 children in the age between one and four years subjected to elective surgery. The patients were randomized into two groups receiving rectally either ibuprofen 40 mg.kg-1.d-1, divided into four equal doses, or placebo in a double blind manner. Additional pain relief was provided by morphine. In the recovery room ibuprofen provided superior pain relief during the first hour and significantly reduced the need of morphine. Heart rate and arterial blood pressure were lower in children who received ibuprofen, probably reflecting better analgesia. The side effects were mild and similar in both groups. We conclude that rectal ibuprofen is a safe analgesic in children in the age between 1 and 4 years and reduces the need of opioids for postoperative pain relief. |
| Databáze: | OpenAIRE |
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