Modulators of Mortality Benefit From Peri-Angioplasty Adjunctive Tirofiban in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
| Autor: | Jung-Chung Hsu, Kuo-Chin Chen, Pen-Chih Liao, Wenpo Chuang, Yu-Wei Chiu, Shin-Rong Ke, Ai-Hsien Li, Yen-Wen Wu, Yuan-Hung Liu, Yen-Ting Yeh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Population 030204 cardiovascular system & hematology 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Internal medicine Angioplasty medicine Humans cardiovascular diseases Myocardial infarction Angioplasty Balloon Coronary education Retrospective Studies Killip class education.field_of_study business.industry Hazard ratio Percutaneous coronary intervention 030229 sport sciences General Medicine Tirofiban medicine.disease Treatment Outcome Cardiology ST Elevation Myocardial Infarction Cardiology and Cardiovascular Medicine business Body mass index Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Circulation Journal. 85:166-174 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-20-0228 |
| Popis: | BACKGROUND Studies investigating the modulators of mortality benefit conferred by peri-angioplasty glycoprotein IIb/IIIa inhibitors in ST-elevation myocardial infarction (STEMI) are still lacking.Methods and Results:A prospective database (n=1,025) of consecutive cases undergoing primary percutaneous coronary intervention for STEMI was retrospectively analyzed. For patients in Killip class I, II or III, IV, the multivariate-adjusted hazard ratios of 30-day all-cause mortality associated with adjunctive tirofiban were 3.873 (95% CI 0.504-29.745; P=0.193), 0.550 (95% CI 0.188-1.609; P=0.275), and 0.264 (95% CI 0.099-0.704; P=0.008), respectively. The P value for a linear trend was 0.032. Patients who had a body mass index (BMI) within 22.9-25.0 kg/m2had a significant benefit from tirofiban (adjusted HR 0.344; 95% CI 0.145-0.814; P=0.015) compared to other BMI groups. The P value for a quadratic trend was 0.012. A novel Killip-BMI score (KBS = 2.5 × Killip category - | BMI - 24 |) was calculated to select the beneficial population. A KBS ≥2 was associated with significant mortality benefit, whereas a KBS |
| Databáze: | OpenAIRE |
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