Financing translation: Analysis of the NCATS rare-diseases portfolio
| Autor: | Andrew W. Lo, N. Nora Yang, John C. McKew, David E. Fagnan |
|---|---|
| Přispěvatelé: | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Operations Research Center, Sloan School of Management, Lo, Andrew W., Fagnan, David E. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Finance
business.industry Modified internal rate of return media_common.quotation_subject education Equity (finance) General Medicine Patient advocacy Translational Research Biomedical Rare Diseases Debt Research Support as Topic Calibration Portfolio Expected return Healthcare Financing Humans Translational science business health care economics and organizations Valuation (finance) media_common |
| Zdroj: | Prof. Lo via Shikha Sharma |
| Popis: | The portfolio of the National Center for Advancing Translational Sciences (NCATS) rare-diseases therapeutic development program comprises 28 research projects initiated at the preclinical stage. Historical data reveal substantially lower costs and higher success rates but longer preclinical timelines for the NCATS projects relative to the industry averages for early-stage translational medical research and development (R&D) typically cited in literature. Here, we evaluate the potential risks and rewards of investing in a portfolio of rare-disease therapeutics. Using a “megafund” financing structure, NCATS data, and valuation estimates from a panel of industry experts, we simulate a hypothetical megafund in which senior and junior debt yielded 5 and 8%, respectively. The simulated expected return to equity was 14.7%, corresponding to a modified internal rate of return of 21.6%. These returns and the likelihood of private-sector funding can be enhanced through third-party funding guarantees from philanthropies, patient advocacy groups, and government agencies. MIT Laboratory for Financial Engineering National Institutes of Health (U.S.). Intramural Research Program National Institutes of Health (U.S.). National Center for Advancing Translational Sciences |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|